抗Xa因子活性检测在血液透析患者低分子肝素抗凝中的应用进展  

Application of anti-Xa factor activity assay in low molecular weight heparin anticoagulation in hemodialysis patients

作　　者：王振兴 徐冷楠 付沛颉 党心 毛永辉 WANG Zhen-xing;XU Leng-nan;FU Pei-jie;DANG Xin;MAO Yong-hui(Department of Nephrology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric medicine,Chinese Academy of Medical Sciences,Beijing 100005,China)

机构地区：[1]北京医院国家老年医学中心北京大学医学部第五临床医学院肾内科,北京100005

出　　处：《中国血液净化》2022年第5期365-368,共4页Chinese Journal of Blood Purification

基　　金：中央高校基本科研业务(BJ-2020-056)。

摘　　要：低分子肝素(low molecular weight heparin,LMWH)是普遍应用的抗凝剂之一,临床常通过抗Xa因子活性来监测其抗凝效应以及评估出血风险,合理的抗Xa因子活性区间在临床指南也都有相应推荐。而具体到血液透析患者中,使用LMWH抗凝时抗Xa因子的监测目标范围尚未形成共识,本综述主要论述抗Xa因子活性检测在血液透析LMWH抗凝中的应用价值,以及具体监测策略的研究进展。Low molecular weight heparin(LMWH)is one of the commonly used anticoagulants.Its anticoagulation effect and bleeding risk are often monitored by the anti-Xa factor activity.Appropriate anti-Xa factor activity range is also recommended in clinical guidelines.As for hemodialysis patients using LMWH,there is no consensus about the target range of anti-Xa factor activity.This review mainly discusses the value of antiXa factor activity assay in LMWH anticoagulation for hemodialysis and the recent progresses in its specific monitoring strategies.

关 键 词：血液透析 低分子肝素 抗Xa因子活性 

分 类 号：R459.5[医药卫生—治疗学]