The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(II) detection and poisoning  

作　　者：Xiang Cheng Shuai Huang Qian Lei Fei Chen Fan Zheng Shibo Zhong Xueyan Huang Bin Feng Xueping Feng Wenbin Zeng 

机构地区：[1]Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China [2]The Molecular Imaging Research Center,Central South University,Changsha 410013,China [3]Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases,Central South University,Changsha 410013,China [4]Xiangya Hospital,Central South University,Changsha 410013,China

出　　处：《Chinese Chemical Letters》2022年第4期1861-1864,共4页中国化学快报（英文版）

基　　金：financial supports from the National Natural Science Foundation of China (Nos. 81971678 and 81671756);the Innovation Fund for Post graduate Students of Central South University (No. 2020zzts827)。

摘　　要：Excessive mercury ions(Hg^(2+)) in the environment can accumulate in human body along with the food chain to cause serious physiological reactions.The fluorescence probes were considered as convenient tool with great potential for Hg^(2+) detection.Most existing probes suffer from aggregation-induced quenching(ACQ) effects and insufficient sensitivity.Herein,a novel type of fluorophore was developed by combining the aggregation-induced emission(AIE) and excited state intramolecular proton transfer(ESIPT) characteristics.Subsequently,a phenyl thioformate group with photoinduced electron transfer(PET)effect was connected to give an efficient "turn-on" probe(HTM),which exhibited good selectivity toward Hg^(2+),short response time(30 min),coupled with extremely low detection limit(LOD=1.68 nmol/L).In addition,HTM was used successfully in real samples,cells and drug evaluation,underlying the superiority of HTM to detect Hg^(2+) in practical applications.

关 键 词：Aggregation-induced emission Excited state intramolecular proton transfer Photoinduced electron transfer Mercury ions Fluorescent imaging 

分 类 号：R99[医药卫生—毒理学] O657.3[医药卫生—药学]