Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer  

作　　者：Xinying Yu Tongyi Shang Guodong Zheng Hailong Yang Yuwei Li Yanjun Cai Guoxi Xie Bin Yang 

机构地区：[1]The Sixth Affiliated Hospital,Department of Biomedical Engineering,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China

出　　处：《Chinese Chemical Letters》2022年第4期1895-1900,共6页中国化学快报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (No. 51903062);Guangdong Basic and Applied Basic Research Foundation (No.2020A1515011320);Science and Technology Projects of Guangzhou(No. 202102020757);Subject Construction Project of Basic Medical Sciences of Guangzhou Medical University (Nos.JCXKJS2021B07, JCXKJS2021D09)。

摘　　要：Ferroustherapy has gained great attention for anti-cancer treatment in recent years. Enlightened by temperature-mediated Fenton reaction in industrial waste water removal, we designed a iron-based polyphenol-coordinated nanomedicines for mild hyperthermia-assisted anti-cancer ferroustherapy. In brief, Fe-GA@BSA nanoparticles was synthesized by self-assembly and sorafenib(SRF) was loaded into Fe-GA@BSA to establish Fe-GA@BSA-SRF nanomedicines. The result nanomedicines can induce ferroptosis in cancer cells by accelerating Fenton reaction. And the photothermal effect of Fe-GA@BSA-SRF was used for mild hyperthermia-assisted ferroustherapy. The nanomedicines performs good anti-cancer therapeutic efficacy by inducing the production of ROS and inhibiting glutathione peroxidase 4(GPX4) expression in vitro and in vivo. Besides, the broad absorption of Fe-GA@BSA-SRF in near infrared region endows it with photoacoustic imaging ability. This study provides ideas about rational design on iron-based nanoparticles for anti-cancer ferroustherapy.

关 键 词：Ferroptosis Metal-polyphenol nanomedicines Fenton reaction Mild hyperthermia Photoacoustic imaging 

分 类 号：TQ460.1[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]