In situ wound sprayable double-network hydrogel: Preparation and characterization  

作　　者：Chenglong Cai Ting Wang Xu Han Shaoqiang Yang Chengteng Lai Tao Yuan Zhangqi Feng Nongyue He 

机构地区：[1]State Key Laboratory of Bioelectronics,National Demonstration Centre for Experimental Biomedical Engineering Education,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Southeast University Jiangbei New Area Innovation Institute,Nanjing 210096,China [3]Nanjing Jinling Hosp,Dept Orthoped,Nanjing 210002,China [4]School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China

出　　处：《Chinese Chemical Letters》2022年第4期1963-1969,共7页中国化学快报（英文版）

基　　金：funding supports from Scene Ray;supported by the National Natural Science Foundation of China (No. 11204033);CMA L’Oreal China Skin Grant 2015 (No.S2015121421);the Open Research Fund of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No. SKLNMKF201803);Southeast University Institution Basal Research Fund。

摘　　要：In clinical settings the wound-dressing was required easy to use and can match the wound area immediately, at the same time they need to have the properties of hemostats, anti-inflammation and promoting wound healing. To get an ideal wound dressing, we developed a type of gel-like wound adhesive patch from spraying double-network hydrogel, which own the properties of self-antibacterial and can promote wound healing. By spraying, the gel-like wound adhesive patch can match the wound area immediately and form a gel-film in 10 s. Sodium carboxymethyl cellulose as p H sensitive materials accelerated the speed to form the gel-film and enhanced ductility of the wound adhesive patch. In vitro experiments show that, this gel-like wound adhesive patch can promote cell proliferation and reduce cell apoptosis.In vivo studies show that, compared with commercialized wound dressings in clinic using, the spraying gel-like wound adhesive patch from our work has a better effect on wound healing. In conclusion, the spraying gel-like wound patch in our work is easy to use and can form a gel-film match on wound area in a short time, also it has the properties of hemostats, anti-inflammation and promoting wound healing.Its feasibility for mass production shows a good potential for commercial use.

关 键 词：HYDROGEL Sodium alginate CHITOSAN Spray method Sodium carboxymethyl cellulose 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]