A highly active and selective chalcogen bond-mediated perchlorate channel  

作　　者：Lin Yuan Peng Jiang Jingliang Hu Huan Zeng Yanping Huo Zhongyan Li Huaqiang Zeng 

机构地区：[1]College of Chemistry and Bioengineering,Hunan University of Science and Engineering,Yongzhou 425199,China [2]Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China [3]Frontier Research Center for Multidisciplinary Sciences,School of Chemistry and Chemical Engineering,Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Chinese Chemical Letters》2022年第4期2026-2030,共5页中国化学快报（英文版）

基　　金：supported by the construct program of applied characteristic discipline in Hunan University of Science and Engineering,the Technology Plan of Guangdong Province(No. 2019A050510042);the Natural Science Foundation of Hunan Province of China (No. 2021JJ30291);Northwestern Polytechnical University。

摘　　要：Artificial membrane transporters that either use chalcogen bonds to facilitate transmembrane flux of anions or show high selectivity toward perchlorate anions are rare.In this work,we report on one such novel monopeptide-based transporter system,featuring both chalcogen bonds for highly efficient anion transport and high transport selectivity toward ClO_(4)^(-) anions.Structurally,these monopeptide molecules associate with each other via H-bonds to produce H-bonded 1D stack that not only one dimensionally but also directionally aligns the terminal bicyclic thiophene motifs to the same side.Functionally,these well-aligned thiophenes create a sulfur-rich transmembrane pathway,combinatorially fine-tunable to enable anions to efficiently cross the membrane in the increasing activity of Cl^(-)<Br^(-)<NO_(3)^(-)<ClO_(4)^(-) via chalcogen bonds,with EC_(50)values of 0.75,0.40,0.37 and 0.093μmol/L(0.3 mol%relative to lipid molecules),respectively.

关 键 词：Synthetic anion channel Chalcogen bonds Monopeptide THIOPHENE PERCHLORATE 

分 类 号：Q503[生物学—生物化学] O641.3[理学—物理化学]