Molecular oxygen-mediated selective hydroxyalkylation and alkylation of quinoxalin-2(1H)-ones with alkylboronic acids  

作　　者：Hongdou Zhang Jun Xu Yani Ouyang Xiaoguang Yue Chenxin Zhou Zhigang Ni Wanmei Li 

机构地区：[1]College of Material,Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University,Hangzhou 311121,China

出　　处：《Chinese Chemical Letters》2022年第4期2036-2040,共5页中国化学快报（英文版）

基　　金：Natural Science Foundation of Zhejiang Province(No. LY21B060009) for financial support。

摘　　要：Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.

关 键 词：Quinoxalin-2(1H)-ones Molecular oxygen Alkyl boric acid C-C C-O bond formations 

分 类 号：O621.25[理学—有机化学]