Enantioselective total synthesis of (+)-vincamine  

作　　者：Fanglin Xue Hengmao Liu Rui Wang Dan Zhang Hao Song Xiao-Yu Liu Yong Qin 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2022年第4期2044-2046,共3页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos. 21991114, 21921002 and 21732005) for financial support。

摘　　要：A catalytic asymmetric total synthesis of(+)-vincamine is presented. Key features of the synthesis include a Pd-catalyzed enantioselective decarboxylative allylation to form the C20 quaternary stereogenic center and a stereoselective iminium reduction to install the critical cis-C20/C21 relative stereochemisty.

关 键 词：Indole alkaloid Decarboxylative allylation Stereoselective iminium reduction Natural product Total synthesis 

分 类 号：TQ283[化学工程—有机化工]