Synthesis and characterization of poly(p-dioxanone)-based degradable copolymers with enhanced thermal and hydrolytic stabilities  

作　　者：Yi-Teng Yan Gang Wu Si-Chong Chen Yu-Zhong Wang 

机构地区：[1]Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE),State Key Laboratory of Polymer Materials Engineering,National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan),College of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Chinese Chemical Letters》2022年第4期2151-2154,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. U19A2095);the Sichuan Science and Technology Program (No. 2017SZDZX0015);the Fundamental Research Funds for the Central Universities。

摘　　要：Herein, we presented a novel biodegradable copolymer via the chain extending reaction of poly(pdioxanone)-co-poly(2-(2-hydroxyethoxy) benzoate)(PPDO-co-PDHB) prepolymer with hexamethylene diisocyanate(HDI) as a chain extender. The structures and molecular weight of PPDO-co-PDHB prepolymer and PPDO-co-PDHB-PU chain-extended copolymer are characterized via hydrogen nuclear magnetic resonance spectroscopy(1 H NMR) and viscosity test. The relationship between the molecular structures and properties of the chain-extended copolymers is established. The PPDO-co-PDHB-PU copolymers possess a better thermal stability comparing with the PPDO homopolymer. The study of mechanical properties shows that the elongation-at-break of PPDO-co-PDHB-PU is much higher than that of PPDO. The investigation of hydrolytic degradation behaviors indicates the degradation rate of PPDO can be controlled by adjusting the PDHB compositions, and proves that chain-extended copolymers exhibit an excellent hydrolytic stability being better than that of PPDO.

关 键 词：Poly(p-dioxanone) Poly(2-(2-hydroxyethoxy)benzoate) Tunable properties Chain extending Controlled degradation 

分 类 号：TQ317[化学工程—高聚物工业]