臭氧大气污染与阿尔兹海默症的研究进展  

Research progress of ozone air pollution and Alzheimer’s disease

作　　者：张孟繁 王秀丽 陈爽 刘佩华 杨伟红[1] 梁璐[1] ZHANG Meng-fan;WANG Xiu-li;CHEN Shuang;LIU Pei-hua;YANG Wei-hong;LIANG Lu(Emergency Department,Affiliated Hospital of Hebei University,Baoding Hebei,071000,China;Neurology Department,Affiliated Hospital of Hebei University,Baoding Hebei,071000,China;Nephrology Department,Affiliated Hospital of Hebei University,Baoding Hebei,071000,China)

机构地区：[1]河北大学附属医院急诊科,河北保定071000 [2]河北大学附属医院神经内科,河北保定071000 [3]河北大学附属医院肾内科,河北保定071000

出　　处：《职业与健康》2022年第10期1417-1421,共5页Occupation and Health

基　　金：国家科技基础资源调查专项基金资助(2017FY101200)。

摘　　要：目前阿尔兹海默症(Alzheimer’s disease,AD)的发病机制存在很多假说,AD的患病可能由神经炎症与氧化应激、β淀粉样(amyloid beta,Aβ)肽沉积及Tau蛋白过度磷酸化、基因突变等机制所致。空气污染是国内较严重的问题之一,O3暴露与AD等神经退行性疾病的相关研究已成为研究热点。我们从流行病学和分子机制方面探讨O3空气污染对AD患病的影响,以期为疾病的预防与控制提供参考。At present,there are many hypotheses about the pathogenesis of Alzheimer’s disease(AD).AD may be caused by neuroinflammation,oxidative stress,amyloid beta(Aβ)peptide deposition,Tau protein hyperphosphorylation and gene mutations.Air pollution is one of the more serious problems in China.The studies on O3exposure and neurodegenerative diseases such as AD has become a hot topic.We will explore the impact of O_(3) air pollution on AD from the aspects of epidemiology and molecular mechanisms,in order to provide reference for clinicians.

关 键 词：臭氧 阿尔兹海默症 空气污染 

分 类 号：R181.34[医药卫生—流行病学]