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作 者:Yongxin Li Man Liu Kunlong Yang Jun Tian
出 处:《Chinese Herbal Medicines》2022年第2期254-262,共9页中草药(英文版)
基 金:supported by the National Natural Science Foundation of China(81774228,31972171,31671944);Natural Science Foundation by Xuzhou City(KC21160);the PAPD of Jiangsu Higher Education Institutions,and Scientific Research Support Project for Teachers with Doctor’s Degrees(Jiangsu Normal University,17XLR034)。
摘 要:Objective:In this study,the aim was to investigate the inhibitory effect of 6,6’-bieckol on the migration and epithelial-mesenchymal transition(EMT)of non-small cell lung cancer(NSCLC)cells,and explore its potential molecular mechanisms.Methods:Cell migration was measured using a CCK8,wound healing,and transwell migration assay.Apoptosis was determined using an Annexin V/propidium iodide staining.Western blotting and immunofluorescence were used to examine the expression level of apoptosis-related proteins and EMT marker proteins.Results:The results showed that 6,6’-bieckol inhibited migration and induced apoptosis of NSCLC cells.Furthermore,6,6’-bieckol had significantly up-regulated the E-cadherin and down-regulated Snail1 and Twist1 transcriptional levels.6,6’-Bieckol might inhibit TGF-β-induced EMT by down-regulating Snail1 and Twist1 and up-regulating E-cadherin in lung cancer cells.Conclusion:It is suggested that 6,6’-bieckol has the potential to be developed as a therapeutic candidate for lung cancer.
关 键 词:APOPTOSIS 6 6’-bieckol epithelial-mesenchymal transition migration non-small cell lung cancer PHLOROTANNIN traditional Chinese medicine
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