Cathayanalactone G and other constituents from leaves and twigs of Callicarpa cathayana  

作　　者：Shuang Gong Bin Cheng Tiantian Sun Xiaoli Li Xinxin Liang Yuan Wang Xiaochang Dai Weilie Xiao 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Research&Development Center for Natural Products,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China

出　　处：《Chinese Herbal Medicines》2022年第2期332-336,共5页中草药（英文版）

基　　金：financially supported by the Natural Science Foundation of China(No.21762048,81860615 and 81903541);Yunnan Applicative and BasicResearch Program(No.2018FY001);the grant of Yunnan Applicative and Basic Research Program(No.2018FA048);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);Project of Innovative Research Team of Yunnan Province(No.202005AE160005);Yun Ling Scholar Project to Wei-e Xiao。

摘　　要：Objective:To study the chemical constituents from the leaves and twigs of Callicarpa cathayana.Methods:The chemical constituents were isolated and purified by column chromatography on silica gel,MCI gel CHP 20 P/P120,Sephadex LH-20,and HPLC.The structures of the compounds were determined by HR-ESI-MS,1 D and 2 D NMR data.Results:A total of 24 compounds were isolated from the 85%methanol extract of leaves and twigs of C.cathayana.They were identified as cathayanalactone G(1),a new diterpene,and 23 known compounds as patagonic acid(2),(-)-16-hydroxycledroda-3,13-dien-16,15-olide-18-oic acid(3),15-methoxypatagonic acid(4),oleanolic acid(5),ursolic acid(6),siaresinolic acid(7),pomolic acid(8),a-amyrin(9),tormentic acid(10),lupeol(11),5,7-dihydroxy-3,4’-dimethoxyflavone(12),5,4’-dihydroxy-3,7,3’-dimethoxyflavone(13),5-hydroxy-3,6,7,4’-tetramethoxyflavone(14),salvigenin(15),kaemferol(16),astragalin(17),pinoresinol 4-O-β-D-glucopyranoside(18),paulownin(19),β-sitosterol(20),β-sitosterolβ-Dglucopyranoside(21),5-hydroxy-coumarin(22),isocopoletin(23),and 4-hydroxycinnamic acid(24).Conclusion:Compound 1 is a new labdane diterpene.Compounds 10,13,16 and 17 are isolated from the genus Callicarpa for the first time.Compounds 7,8,9,12,14,23 and 24 are reported from C.cathayana for the first time.

关 键 词：Callicarpa cathayana H.T.Chang cathayanalactone G FLAVONOIDS labdane diterpene TRITERPENOIDS 

分 类 号：R284.1[医药卫生—中药学]