Three new triterpenoid saponins from Aralia echinocaulis  

作　　者：Mengyun Yan Yajia Sun Ling Ding Jiuxu Sun Jingzhu Song Wenbin Zhou Lingpeng Pei 

机构地区：[1]Key Laboratory of Ethnic Medicine,Ministry of Education,Minzu University of China,Beijing 100081,China

出　　处：《Chinese Herbal Medicines》2022年第2期337-341,共5页中草药（英文版）

基　　金：National Natural Science Foundation of China(No.81673769)for funding the experiment。

摘　　要：Objective:To study the active ingredients in the root bark of Aralia echinocaulis.Methods:Three triterpenoid saponins were separated from the 70%ethanol extracts and purified by column chromatography and their structures were determined by spectroscopic analysis.Compound 1 and 3 were evaluated for antioxidant activity by the in vitro DPPH free radical scavenging ability and the protective effect of OH-induced DNA oxidative damage.Results:Compound 1 was a new type of triterpenoid saponin,named as echinocaulisaglycone 3-O-β-Dglucopyranoside(echinocaulisaponin A),and it had good antioxidant activity.Compound 2 was similar to compound 1,named as 1-hydroxyl-echinocaulisaglycone 3-O-β-D-glucopyranoside(echinocaulisaponin B).Compound 3 was also a new type of triterpenoid saponin,named as echinocaulisaglyconeⅡ3-O-a-L-arabinopyranosyl-(1’’→4’)-β-D-glucopyranosiduronic acid(echinocaulisaponin C),and its antioxidant activity was weaker than compound 1.Conclusion:In this study,three new compounds were discovered and two of them were carried out in vitro anti-oxidation studies,laying the foundation for further research on the treatment of related diseases(cardiovascular disease,arthritis,age-related macular degeneration,etc.)through anti-oxidation or quenching free radical function.

关 键 词：Aralia echinocaulis Hand.-Mazz. echinocaulisaponin A echinocaulisaponin B echinocaulisaponin C triterpenoid saponin 

分 类 号：R284[医药卫生—中药学]