槐杞黄颗粒辅助治疗儿童持续性免疫性血小板减少症的有效性与安全性研究  被引量:2

Efficacy and safety of Huaiqihuang granule in the adjuvant treatment of persistent immune thrombocytopenia in children

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作  者:刘燕[1] 戴莉[1] 黄倩[1] 蔡力肖[1] 李岩 孙语眉 张攀 李红乔 Liu Yan;Huang Qian;Cai Lixiao;Sun Yumei;Zhang Pan;Li Hongqiao(Baoding children hospital,Baoding 071000,China)

机构地区:[1]保定市儿童医院,保定071000

出  处:《湖南师范大学学报(医学版)》2022年第2期160-163,共4页Journal of Hunan Normal University(Medical Sciences)

摘  要:目的:通过临床观察探讨槐杞黄颗粒辅助儿童治疗持续性血小板减少症的疗效,并对其不良反应进行安全评估.方法:选择为2016年1月~2019年8月在我院就诊ITP患儿160例,采用随机数字表法,随机分为观察组和对照组,每组各80例.对照组采用持续性免疫性血小板减少症的经典治疗,观察组在以上基础联合使用槐杞黄颗粒,治疗3个月.观察两组患者的临床疗效、血小板计数(PLT)、T淋巴细胞亚群比较:CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平、凝血功能指标,包括部分活化凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原时间(PT)、出血症状消失时间、住院时长和不良反应.结果:观察组的临床有效率为95.00%,对照组的临床有效率为90.00%,观察组的临床有效率高于对照组,但是没有统计学差异;两组患者治疗前和治疗一个月后的PLT数目相比,差异不明显,治疗2、3个月后观察组的PLT数目高于对照组,且差异具有统计学意义;治疗后两组患者的CD4^(+)和CD4^(+)/CD8^(+)均上升,CD8^(+)下降,且观察组的幅度更大,差异具有统计学意义,两组患者治疗前、后凝血功能指标APTT、FIB和PT水平相比,差异不明显,观察组出血症状消失时间和住院时长都要短于对照组,观察组未出现严重的不良反应.结论:槐杞黄颗粒辅助治疗儿童持续性免疫性血小板减少症,可以调节CD4^(+)/CD8^(+)/平衡,加快PLT的提升速度,缩短出血症状消失时间和住院时长,用药安全,值得临床推广.Objective To investigate the efficacy of Huaiqihuang granule in the treatment of persistent thrombocytopenia in children,and to evaluate the safety of its adverse reactions.Methods 160 children with ITP treated in our hospital from January 2016 to August 2019 were randomly divided into observation group and control group,with 80 cases in each group.The control group was treated with the classic treatment of persistent immune thrombocytopenia,and the observation group was treated with Huaiqihuang granule for 3 months.The clinical efficacy,platelet count(PLT),T lymphocyte subsets,CD4^(+),CD8^(+),CD4^(+)/CD8^(+)levels,coagulation function indexes,including partially activated thromboplastin time(APTT),fibrinogen(FIB),prothrombin time(PT),disappearance time of bleeding symptoms,length of hospital stay and adverse reactions,were observed.Results The clinical effective rate of the observation group was 95.00%,and that of the control group was 90.00%.The clinical effective rate of the observation group was higher than that of the control group,but there was no significant difference;There was no significant difference in the number of PLT between the two groups before treatment and one month after treatment.After 2 and 3 months of treatment,the number of PLT in the observation group was higher than that in the control group,and the difference was statistically significant;After treatment,CD4^(+)and CD4^(+)/CD8^(+)of the two groups increased and CD8^(+)decreased,and the range of the observation group was greater,the difference was statistically significant.There was no significant difference between the two groups in the levels of APTT,FIB and Pt before and after treatment.The elimination time of bleeding symptoms and length of hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant,There were no serious adverse reactions in the observation group.Conclusion Huaiqihuang granule in the adjuvant treatment of children with persistent immune thromboc

关 键 词:槐杞黄颗粒 持续性血小板减少症 儿童 糖皮质激素 人免疫球蛋白 

分 类 号:R541[医药卫生—心血管疾病]

 

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