摩罗丹联合常规西药治疗慢性萎缩性胃炎的Meta分析和试验序贯分析  

Meta Analysis and Trial Sequential Analysis of Moluodan Combined with Conventional Western Medicine in the Treatment of Chronic Atrophic Gastritis

作　　者：俞赟丰 上官雪丽 王燚霈[2] 朱莹 YU Yunfeng;SHANGGUAN Xueli;WANG Yipei;ZHU Ying(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007 Hunan,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005 Hunan,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中药新药与临床药理》2022年第5期714-720,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重点研发计划项目(2017YFC1700601);国家自然科学基金项目(81874466)。

摘　　要：目的系统评价摩罗丹联合常规西药治疗慢性萎缩性胃炎(CAG)的临床疗效。方法检索中国知网、中国生物医学文献数据库、Embase、PubMed等数据库关于摩罗丹联合常规西药治疗CAG的随机对照临床试验,时间范围均从建库至2021年9月。对所获得的随机对照临床试验进行Meta分析和试验序贯分析。结果共纳入10项研究,样本量1070例。与常规西药相比,摩罗丹联合常规西药治疗CAG能显著提高临床综合有效率[RR=1.24,95%CI=(1.16,1.31),P<0.00001]、症状有效率[RR=1.25,95%CI=(1.14,1.38),P<0.00001]、胃镜有效率[RR=1.42,95%CI=(1.25,1.63),P<0.00001]和病检有效率[RR=1.46,95%CI=(1.30,1.65),P<0.00001]。试验序贯分析显示临床综合有效率的结果具有确切证据。Harbord回归显示不存在发表偏倚(P=0.48)。证据质量评价显示临床综合总有效率的证据质量为中,症状有效率、胃镜有效率和病检有效率的证据质量为低。结论摩罗丹联合常规西药治疗CAG能有效提高临床疗效,具有较好的临床应用的前景。Objective To systematically evaluate the clinical efficacy of Moluodan combined with conventional western medicine in the treatment of chronic atrophic gastritis(CAG).Methods The databases of CNKI,CBM,VIP,Wanfang,Embase,PubMed,and the Cochrane Library and Web of Science were searched,and the time was limited from the establishment of the databases to September 2021.The published randomized controlled trials were meta-analyzed and sequential analyzed.Results A total of 10 studies were included,with a total sample size of 1070 cases.Compared with conventional western medicine,Moluodan combined with conventional western medicine in the treatment of CAG can significantly improve the clinical comprehensive effective rate[RR=1.24,95%CI=(1.16,1.31),P<0.00001],symptom effective rate[RR=1.25,95%CI=(1.14,1.38),P<0.00001],gastroscopy effective rate[RR=1.42,95%CI=(1.25,1.63),P<0.00001]and disease examination effective rate[RR=1.46,95%CI=(1.30,1.65),P<0.00001].The trial sequential analysis showed that the results of clinical comprehensive efficiency had a definite evidence.Harbord regression showed no publication bias(P=0.48).The evaluation of evidence quality showed that the evidence quality of clinical comprehensive efficiency was medium,and the evidence qualities of symptom efficiency,gastroscopy efficiency and disease examination efficiency were low.Conclusion Moluodan combined with conventional western medicine in the treatment of CAG can effectively improve the clinical efficacy and has good prospect in clinical application.

关 键 词：摩罗丹 常规西药 慢性萎缩性胃炎 META分析 试验序贯分析 

分 类 号：R285.6[医药卫生—中药学]