育亨宾类似物Sempervilam的全合成  

Total Synthesis of Yohimbane Analogue Sempervilam

作　　者：谭新刚 施小新[1] 衣学玉 Tan Xingang;Shi Xiaoxin;Yi Xueyu(School of Pharmacy,East China University of Science and Technology,Shanghai,200237)

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《化学通报》2022年第6期755-758,共4页Chemistry

摘　　要：以庚二酸为起始原料,经过十步反应,得到目标产物育亨宾类似物Sempervilam,总收率19%。其结构经^(1)H NMR、^(13)C NMR、IR和MS表征。此法绿色环保、成本较低,适合工业化生产。The yohimbane analogue sempervilam was prepared from heptanediacid. The total yield of the ten steps is 19%. The structures of all compounds were characterized by ^(1)H NMR,^(13)C NMR, IR and MS. The method is environmentally friendly, lower cost, and has potential for industrial production.

关 键 词：育亨宾类似物 Sempervilam 合成 

分 类 号：TQ460.1[化学工程—制药化工]