荧光标记的锰羰基化合物一氧化碳释放研究  

The Study of Photo Initiation Carbon Monoxide Releasing from Manganese Carbonyl Complex

作　　者：王雪梅 张俊蝶 李卓芹 马明慧 汪慧云 姜秀娟[1] WANG Xuemei;ZHANG Jundie;LI Zhuoqin;MA Minghui;WANG Huiyun;JIANG XiuJuan

机构地区：[1]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《上海化工》2022年第3期23-27,共5页Shanghai Chemical Industry

基　　金：浙江省大学生科技创新项目(2021R417003);嘉兴学院大学生研究训练项目(SRT);浙江省自然科学基金资助项目(LY18H300006)。

摘　　要：利用五羰基溴化锰、5-氨基荧光素和2-吡啶甲醛通过一步法反应合成了一种新型的锰羰基化合物(1),该化合物具有暗稳定性,但对光敏感,经可见光照射后其羰基可以解离并以一氧化碳(CO)的形式释放出来,可作为光诱导一氧化碳释放分子(photo CORM)。研究表明,化合物1分解释放CO的过程符合一级反应动力学模型,而且可以通过选择不同光源来调控CO释放速率。另外,该锰羰基化合物在500~700 nm可以发射较强荧光,可以作为潜在的荧光标记的一氧化碳释放分子(CORMs),为研究细胞及生物体内CORMs的分布及CO释放提供可能。In this article,a manganese carbonyl compound(1)was synthesized by the one step reaction of Mn(CO)5Br,5-aminofluorescein and pyridine-2-carboxaldehyde.This complex was stable in dark,but light-sensitive.It’s carbonyl group can be dissociated by visible light and released carbon monoxide(CO),which can serve as photo induced CO-releasing molecule(photoCORM).The kinetics analysis shows that the decomposition of complex 1 to release CO conforms to the quasi-first-order reaction model and the CO release rate can be easily realized by selecting different light sources.Additionally,the manganese carbonyl compound can emit strong fluorescence at 500~700 nm,and it can be used as a potential fluorescent-labeled carbon monoxide releasing molecules(CORMs),which provides the possibility to study the release of CORMs in vivo.

关 键 词：光诱导 一氧化碳释放剂 荧光素 锰羰基化合物 荧光 

分 类 号：O614.8[理学—无机化学]