粤闽赣边区儿童OSA患者8-异前列腺素F2α与AHI的相关性分析  

Correlation analysis of 8-isoprostaglandin F2α and AHI in children with OSA in the border area of Guangdong,Fujian and Jiangxi

作　　者：王晓锋[1] 李嘉[1] 卢静成 黎雄文[1] 朱财明 李世嵘[1] Wang Xiao-feng;Li Jia;Lu Jing-cheng;Li Xiong-wen;Zhu Cai-ming;Li Shi-rong(Second Department of Otolaryngology,Meizhou People's Hospital,Meizhou 514031,China)

机构地区：[1]梅州市人民医院耳鼻咽喉二科,梅州514031

出　　处：《湖南师范大学学报（医学版）》2022年第1期57-60,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：梅州市人民医院科研培育项目(PY-C2021004)。

摘　　要：目的:探讨粤闽赣边区儿童阻塞性睡眠呼吸暂停综合征(obstructive sleepapnea,OSA)患者8-异前列腺素F2α与睡眠呼吸暂停低通气指数(apnea hypopnea index,AHI)的相关性。方法:96例粤闽赣边区儿童OSA患者,根据病情严重程度不同分为轻度组、中度组、重度组,32例健康体检儿童作为对照组。比较各种血浆8-异前列腺素F2α水平、AHI水平、中性粒细胞数、单核细胞数、血清抗体水平。结果:对照组与轻度组、中度组、重度组,轻度组与重度组、中度组与重度组8-异前列腺素F2α水平差异均有统计学意义。皮尔逊相关性分析发现血浆8-异前列腺素与AHI呈正相关。各组中性粒细胞比率、单核细胞比率差异均无统计学意义。各组中性粒细胞数、单核细胞数差异有统计学意义。重度组单核细胞数多于对照组,中度组单核细胞数多于对照组,轻度组单核细胞数少于中度组、重度组及对照组。中度组、重度组中性粒细胞数多于对照组。4组IgM差异有统计学意义,轻度组IgM低于对照组,也低于重度组。各组IgA、IgG差异无统计学意义。结论:OSA患者血浆8-异前列腺素F2α水平显著高于对照组,与病情严重程度有关。8-异前列腺素F2α与AHI呈正相关。Objective To investigate the correlation between 8-isoprostaglandin F2α and apnea hypopnea index (AHI) in children with obstructive sleepapnea (OSA) in Guangdong,Fujian and Jiangxi border areas.Methods 96 children with OSA in Guangdong,Fujian and Jiangxi border areas were divided into mild,moderate,and severe groups according to the severity of their illnesses.32 healthy children served as the control group.Compare various plasma 8-isoprostaglandin F2α levels,AHI levels,neutrophil counts,monocyte counts,and serum antibody levels.Results There were statistically significant differences in the levels of 8-isoprostaglandin F2α between the control group and the mild group,moderate group,severe group,mild group and severe group,moderate group and severe group.Pearson correlation analysis found that plasma 8-isoprostaglandin was positively correlated with AHI.There was no significant difference in the ratio of neutrophils and monocytes in each group.There were statistically significant differences in the number of neutrophils and monocytes in each group.The number of monocytes in the severe group was more than that of the control group,the number of monocytes in the moderate group was more than that of the control group,and the number of monocytes in the mild group was less than that of the moderate group,severe group and control group.The number of neutrophils in the moderate and severe groups was more than that in the control group.The difference in IgM between the 4 groups was statistically significant.The IgM of the mild group was lower than that of the control group,and it was also lower than that of the severe group.Conclusion The plasma 8-isoprostaglandin F2α level of OSA patients is significantly higher than that of the control group,which is related to the severity of the disease.8-Isoprostaglandin F2α is positively correlated with AHI.

关 键 词：儿童 阻塞性睡眠呼吸暂停综合征 8-异前列腺素F2Α 睡眠呼吸暂停低通气指数 

分 类 号：R766[医药卫生—耳鼻咽喉科]