支原体IgM抗体阳性社区获得性肺炎患者凝血功能及血清炎性因子水平变化及意义  

The Changes and Significance of Coagulation Function and Serum Inflammatory Factor Levels in Patients with Community Acquired Pneumonia and Mycoplasma IgM Antibody Positive

作　　者：李朋玲 王彤彤 Li Peng-ling;Wang Tong-tong(Department of Respiratory and Critical Care Medicine,Huai'an First People's Hospital,Huaian 223300,Chirm)

机构地区：[1]淮安市第一人民医院呼吸与危重症医学科,淮安223300

出　　处：《湖南师范大学学报（医学版）》2022年第1期173-175,共3页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:支原体IgM抗体阳性社区获得性肺炎(Community acquired pneumonia,CAP)患者凝血功能及血清炎性因子水平变化及意义。方法:本研究观察对象为2018年1月~2018年9月我院收治的150例CAP患者,所有患者均进行血清支原体IgM抗体检测,设为IgM抗体阳性组与IgM抗体阴性组,选择40例年龄、性别配对的同期入院体检正常人群,设为对照组。全自动凝血分析仪检测两组患者凝血酶原时间(prothrombin time,PT)、纤维蛋白降解产物(Fibrin degradation products,FDP)等凝血功能指标,采用酶联免疫吸附试验(Enzyme linked immunosorbent assay,ELISA)检测血清C反应蛋白(C reactive protein,CRP)、降钙素原(Calcitonin,PCT)等炎性因子水平。结果:抗体阳性组血浆D-二聚体(D-Dimer)、FDP水平显著高于IgM抗体阴性组与对照组,且IgM抗体阴性组显著高于对照组;抗体阳性组PT、活化的部分凝血活酶时间(Activated part Thromboplastin time,APTT)显著低于IgM抗体阴性组与对照组,IgM抗体阴性组与对照组差异无统计学意义;抗体阳性组血清PCT、CRP、白细胞介素6(Interleukin,IL-6)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)水平显著高于IgM抗体阴性组与对照组,且IgM抗体阴性组显著高于对照组。结论:支原体IgM抗体阳性CAP患者较支原体IgM抗体阴性者炎性反应血液高凝状态更重,建议结合凝血功能指标、炎症指标进行CAP病原体早期鉴别,开展CAP的针对性治疗。Objective To study the changes and significance of coagulation function and serum inflammatory factor levels in patients with community acquired pneumonia (CAP) and mycoplasma IgM antibody positive.Methods A total of 150 patients with CAP admitted to our hospital from January 2018 to September 2018 were selected as the observational subjects.All patients were tested for serum mycoplasma IgM antibody,which were divided into the IgM antibody positive group and the IgM antibody negative group.The normal group of people who were admitted to the hospital during the same period of gender matching was set as the control group.Automated coagulation analyzer was used to detect prothrombin time (PT),fibrin degradation products (FDP) and other coagulation function indexes.Enzyme linked immunosorbent assay (ELISA) was used to detect serum C-reactive protein (CRP),procalcitonin (PCT) and other inflammatory factors.Results The levels of D-Dimer and FDP in the antibody positive group were significantly higher than those in the IgM antibody negative group and the control group,and the IgM antibody negative group was significantly higher than the control group;PT and activated partial thromboplastin time (APTT) in the antibody positive group were significantly lower than those in the IgM antibody negative group and the control group.There was no significant difference between the IgM antibody negative group and the control group.The levels of PCT,CRP,Interleukin (IL-6),and tumor necrosis factor α (TNF-α) in the antibody-positive group were significantly higher than those in the IgM antibody-negative group and the control group,and the IgM antibody was negative.The group was significantly higher than the control group.Conclusion Mycoplasma IgM antibody-positive CAP patients have more hypercoagulable state than the mycoplasma IgM antibody-negative inflammatory reaction.It is recommended to combine the coagulation function index and inflammation index for early identification of CAP pathogens,and carry out targeted treatment of CA

关 键 词：支原体IgM抗体阳性 社区获得性肺炎 凝血功能 炎性因子 

分 类 号：R446.5[医药卫生—诊断学]