不同剂量右美托咪定持续输注复合全身麻醉对老年肺癌根治术患者的效果分析  

Analysis on the Effects of Different Doses of Dexmedetomidine for Continuous Infusion Combined with General Anesthesia on Elderly Patients with Radical Lung Cancer Surgery

作　　者：关柏锐[1] 黄丹辉[1] GUAN Bairui;HUANG Danhui(Department of Anesthesiology,Jiangmen Central Hospital,Jiangmen 529030,China)

机构地区：[1]江门市中心医院麻醉科,广东江门529030

出　　处：《临床医学工程》2022年第6期815-816,共2页Clinical Medicine & Engineering

摘　　要：目的 分析不同剂量右美托咪定持续输注复合全身麻醉应用于老年肺癌根治术患者的效果。方法 51例老年肺癌根治术患者随机分为两组,对照组给予低剂量右美托咪定持续输注复合全身麻醉,观察组给予高剂量右美托咪定持续输注复合全身麻醉,比较两组的镇痛镇静效果、炎症水平和不良反应。结果 观察组术后2 h、 4 h、 12 h、 24 h的VAS评分和Ramsay评分均显著优于对照组(P<0.05)。术后1 d、 2 d,两组的CRP、 TNF-α水平均上升,但观察组的CRP、 TNF-α水平均显著低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 与小剂量右美托咪定相比,大剂量右美托咪定持续输注复合全身麻醉应用于老年肺癌根治术患者的镇痛镇静效果较好,可更有效地控制炎性因子水平,且不增加不良反应。Objective To analyze the effects of different doses of dexmedetomidine for continuous infusion combined with general anesthesia applied in elderly patients with radical lung cancer surgery. Methods 51 elderly patients with radical lung cancer surgery were randomly divided into two groups. The control group received low-dose dexmedetomidine for continuous infusion combined with general anesthesia, while the observation group received high-dose dexmedetomidine for continuous infusion combined with general anesthesia. The analgesic and sedative effects, inflammation levels and adverse reactions of the two groups were compared. Results The VAS scores and Ramsay scores at 2 h, 4 h, 12 h, and 24 h after surgery of the observation group were significantly better than those of the control group(P<0.05). At 1 d and 2 d after surgery, the levels of CRP and TNF-α in both groups increased, but the levels of CRP and TNF-α of the observation group were significantly lower than those of the control group(P <0.05). No significant difference was found in the incidence of adverse reactions between the two groups(P >0.05). Conclusions Compared with low-dose dexmedetomidine, high-dose dexmedetomidine for continuous infusion combined with general anesthesia applied in elderly patients with radical lung cancer surgery has better analgesic and sedative effects, and can more effectively control the levels of inflammatory factors without increasing adverse reactions.

关 键 词：不同剂量 右美托咪定 舒芬太尼 全身麻醉 老年肺癌根治术 

分 类 号：R614[医药卫生—麻醉学]