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作 者:Fang-Fang Qian You-Hua He Xiao-Hui Du Hua-Xiang Lu Ren-Hong He Jian-Zhong Fan
机构地区:[1]Department of Rehabilitation Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China [2]Department of Comprehensive Ward,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China
出 处:《Neural Regeneration Research》2023年第2期368-374,共7页中国神经再生研究(英文版)
基 金:supported by the President Foundation of Nanfang Hospital,Southern Medical University,No.2016Z003(50107021)(to JZF).
摘 要:Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.
关 键 词:brain-derived neurotrophic factor moderate traumatic brain injury neurological dysfunction neurological improvement N-methyl-D-aspartic acid receptor repetitive transcranial magnetic stimulation synaptic plasticity SYNAPTOPHYSIN traumatic brain injury TRKB
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