α-烯基取代氨基酸酯的合成研究  

Synthesis of α-Alkenyl Substituted Amino Acid Esters

作　　者：张亚凤 李鹏飞 刘婷 黎樱子 刘一豪 唐石[1] ZHANG Yafeng;LI Pengfei;LIU Ting;LI Yingzi;LIU Yihao;TANG Shi(College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China)

机构地区：[1]吉首大学化学化工学院,湖南吉首416000

出　　处：《化工技术与开发》2022年第6期21-24,共4页Technology & Development of Chemical Industry

基　　金：吉首大学创新创业训练计划项目(S202010531037)。

摘　　要：以商业可得的蛋氨酸甲酯盐酸盐为起始原料,通过亲核酰基取代反应、氧化反应、消去反应等6个步骤,得到2-(二苄基氨基)丁-2-烯酸甲酯。通过优化反应的影响因素,确定了制备α-烯基取代氨基酸酯的最佳反应条件。该合成工艺路线为合成含多官能化α-烯基取代氨基酸酯结构的药物中间体,提供了一种便利途径。The commercially available methionine methyl ester hydrochloride was used as the starting material,and through six steps of nucleophilic acyl substitution reaction,oxidation reaction and elimination reaction,2-(dibenzylamino) butyl-2-enoic acid methyl ester was prepared.The optimum reaction conditions for the preparation of α-alkenyl substituted amino acid esters were determined by optimizing the reaction factors.This synthetic method provided a convenient way for the synthesis of pharmaceutical intermediates containing polyfunctional α-alkenyl substituted amino acid esters.

关 键 词：氨基酸酯 α-烯基取代氨基酸酯 蛋氨酸甲酯盐酸盐 取代反应 脱保护 

分 类 号：O623.624[理学—有机化学]