Mixing Dynamics and Synthesis Performance of Staggered Herringbone Micromixer for Limit Size Lipid Nanoparticles  

作　　者：Shuai Zhang Yunlong Fan Chenmu Xue Yuanzhan Yang Xiaoqiong Li Xiaodong Chen Yulin Deng 

机构地区：[1]School of Aerospace Engineering,Beijing Institute of Technology,Beijing 100081,China [2]Institute of Engineering Medicine,Beijing Institute of Technology,Beijing 100081,China [3]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [4]Key Laboratory of Convergence Medical Engineering System and Healthcare Technology,Ministry of Industry and Information Technology,Beijing 100081,China

出　　处：《Journal of Beijing Institute of Technology》2022年第3期293-301,共9页北京理工大学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.11772343);the Beijing Institute of Technology Research Fund Program for Young Scholars.

摘　　要：Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of micromixer,this paper carries out a high-fidelity numerical simu-lation and a parametrial experimental study on a well-established design.A passive tracer is induced in the numerical simulation to analyze mixing dynamics induced by the staggered herring-bone structures.Three effects are identified to reveal the underlying mechanisms,including folding,stretching,and splitting.To the authors’knowledge,the splitting effect is identified for the first time by the isosurface of the passive tracer,to show the high efficiency of the staggered herring-bone design.The micromixer is then used to synthesize lipid nanoparticles by mixing a mixture of lipid and poly(lactic-co-glycolic acid)(PLGA)solutions with deionized water.Under a wide mass ratio of lipid and PLGA solutions,nanoparticles with good monodispersity are synthesized to reflect the good compatibility of the micromixer and the mixture.In addition,an optimized mass ratio is identified from the parametrical experiment.

关 键 词：mixing dynamics staggered herringbone micromixer FOLDING STRETCHING splitting 

分 类 号：TB383.1[一般工业技术—材料科学与工程]