Rh表型配合性输注红细胞疗效  

The Efficacy of Rh Phenotype Matched Blood Transfusion

作　　者：贾军会[1] 高晓云[1] 田华[1] 白薇[1] 王新华[1] JIA Jun-Hui;GAO Xiao-Yun;TIAN Hua;BAI Wei;WANG Xin-Hua(Department of Blood Transfusion,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院输血科,北京100049

出　　处：《中国实验血液学杂志》2022年第3期865-869,共5页Journal of Experimental Hematology

摘　　要：目的:分析评价Rh表型配合性输注红细胞的疗效。方法:回顾性分析Rh表型配合性输注与非配合性输注、初次非配合性输注与再次非配合性输注红细胞后患者血红蛋白增长量和溶血相关检测指标的变化。结果:本研究评价了120例反复输血患者共计674次输血效果,Rh表型配合性输注每U红细胞血红蛋白增长量优于非配合性输注[(33.397±1.475)g/U vs (29.951±1.304)g/U,P=0.033],而初次非配合性输注与再次非配合性输注后血红蛋白增长量无统计学差异[(28.942±2.083)g/U vs(30.686±1.737)g/U,P=0.589]。输血后溶血相关检测显示,乳酸脱氢酶的升高与红细胞洗涤、辐照、效期、再次非配合性输注等因素均有相关性(均P<0.05);再次非配合性输注后间接胆红素、直接胆红素、总胆红素水平较初次非配合性输注均有不同程度升高(均P<0.05)。结论:对于需要反复输血的患者,Rh表型配合性输注可以减少抗原暴露的概率,增强输血疗效,是保证患者输血安全的重要环节。Objective: To analyze and evaluate the efficacy of Rh phenotype matched blood transfusion. Methods:The increasing of hemoglobin(Hb) and hemolysis tests in the patients treated by Rh matched red blood cells or not, as well as the first time unmatched transfusions and the unmatched transfusions happened again after a period(≥10 d) werer etrospectively analyzed. Results: A total of 674 times transfusions in 120 patients were evaluated. The increasing of Hbi n each unit was higher in the patients treated by Rh matched blood transfusion(vs unmatched) [(33.397±1.475) g/U vs(29.951±1.304) g/U, P=0.033], while the increasing of Hb at first time unmatched transfusion and the second timeu nmatched transfusion was not statistically different[(28.942±2.083) g/U vs(30.686±1.737) g/U, P=0.589]. Thel evel of lactate dehydrogenase were related to erythrocyte washing, irradiation, period of validity and the second time unmatched transtusion(all P<0.05);the levels of total bilirubin(TBil), direct bilirubin(DBil) and indirect bilirubin(IBil)b etween the first time unmatched transfusion and the second time unmatched transfusion were statistically different(all P<0.05). Conclusion: For the patients need multiple blood transfusions, Rh phenotype matched blood transfusion can r educe the exposure to Rh allogenic antigens, improve the efficacy and ensure the safety of blood transfusion.

关 键 词：Rh表型 配合性输注 输血疗效 

分 类 号：R457.11[医药卫生—治疗学]