EB病毒感染患者骨髓细胞形态学特点分析  

Morphological Characteristics of Bone Marrow Cells in Patients with EB Virus Infection

作　　者：贺利艳[1] 杨峥[1] 黄春妮[1] 黄建 HE Li-Yan;YANG Zheng;HUANG Chun-Ni;HUANG Jian(Department of Clinical Medical Laboratory,The First Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学第一附属医院检验科,广西南宁530021

出　　处：《中国实验血液学杂志》2022年第3期908-912,共5页Journal of Experimental Hematology

摘　　要：目的:回顾分析EB病毒(EBV)感染患者的骨髓细胞形态学的特征,探讨骨髓细胞形态学对早期识别EBV感染的诊断价值。方法:收集广西医科大学第一附属医院2018年1月至2021年5月EBV-DNA检测阳性的患者33例作为研究对象,进行骨髓细胞形态学检查、外周血细胞分析,用统计学方法分析其在疾病诊断中的意义。结果:EBV感染患者取材33例,满意度100%。临床诊断IM 7例,EBV-HLH 17例,淋巴瘤3例,EBV相关淋巴增殖性疾病2例,未能明确诊断4例。其中31例出现骨髓增生活跃或以上,26例出现粒系增生活跃或以上,21例出现红系增生活跃或以上,17例出现巨核细胞产血小板功能减低。骨髓异常成分主要有异型淋巴细胞(33例),噬血细胞(22例),异常组织细胞(10例)。结论:根据骨髓粒、红、巨三系造血细胞增生情况的改变,以及异型淋巴细胞细胞、噬血细胞、异常组织细胞等异常成分的出现,骨髓细胞形态学检查可以提示感染EBV的可能性,对早期识别EBV感染有一定的诊断价值。Objective: Reviewand analyze the characteristics of bone marrow cell morphology in patients with Epstein-Barr virus(EBV) infection, and explore the diagnostic value of bone marrow cell morphology for the early identification of EBV infection. Methods: A total of 33 patients with EBV-DNA positive detection in the First Affiliated Hospital of Guangxi Medical University from January 2018 to May 2021 were collected as the research objects. Bone marrow cell morphology and peripheral blood cell analysis were performed, and the significance in disease diagnosis was analyzed by statistical methods. Results: The sampling satisfaction of 33 patients with EBV infection was 100%. In the clinical diagnosis of all cases, 7 cases were IM, 17 cases were EBV-HLH, 3 cases were lymphoma, 2 cases were EBV-associated lymphoid hyperplasia, and 4 cases were not diagnosed. Among them, 31 patients had active bone marrowhyperplasia or above, 26 patients had active granulocytic hyperplasia or above, 21 patients had active erythroid hyperplasia or above, and 17 cases of megakaryocyte production platelet function decreased. The abnormal components of bone marrow mainly indude atypical lymphocyte cells(33 cases), hemophagocytic cells(22 cases), abnormal histiocyte(10 cases). Conclusion: According to the proliferation of granulocytes, erythrocytes and megakaryocytes in the bone marrow, and the emergence of abnormal components such as atypical lymphocytes, hemophagocyte, abnormal histiocyte. Bone marrow cell morphological examination can indicate the possibility of EBV infection, which is certain diagnostic value for early identification of EBV infection.

关 键 词：EB病毒感染 骨髓细胞形态学 特征 早期识别 

分 类 号：R511[医药卫生—内科学]