间充质干细胞来源的胞外囊泡免疫调节活性及其在造血干细胞移植中的应用  

Research Progress on Immunomodulatory Activity and Clinical Application of Mesenchymal Stem Cells-Derived Extracellular Vesicles——Review

作　　者：赵洁[1] 姜言 郝思国[1] ZHAO Jie;JIANG Yan;HAO Si-Guo(Department of Hematology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院血液科,上海200092

出　　处：《中国实验血液学杂志》2022年第3期955-958,共4页Journal of Experimental Hematology

摘　　要：骨髓间充质干细胞(MSC)因其自我更新、多向分化以及免疫调节等特性已被广泛应用于组织再生与修复工程、移植物抗宿主病(GVHD)以及免疫性疾病的治疗等方面。MSC释放的胞外囊泡(MSC-EV)通过作用于靶细胞,介导细胞间信息交流和传递,并激活相关的信号通路,调控细胞的功能和生物学行为。近年的研究发现MSC-EV具有其母细胞的生物学功能,作为MSC的“使者”,尤其是在免疫调节以及造血干细胞移植免疫等方面具有重要的应用潜能。因此,MSC-EV被认为是治疗自身免疫相关性疾病和GVHD的潜在治疗工具,具有广阔的临床应用前景。本文对MSCEV的免疫调节活性和其在造血干细胞移植免疫中的研究进展作一综述,并对其未来临床应用的潜能进行了探讨。Mesenchymal stem cells(MSC) have been widely used in tissue regeneration and treatment graft versus host disease(GVHD) and immune diseases due to their self-renewal, multi-differentiation and immunoregulatory potential. However, more and more scholars begin to put weight on the MSC-derived extracellular vesicles(MSC-EV)for its regulation of inflammation and immunity. MSC-EV can activate the relevant signal pathways and regulate the function and biological behaviors of cells via acting on target cells and mediating communication between cells. MSCEV has important potential clinical applications for its powerful immunomodulatory and hematopoietic regulatory functions. It is considered as a potential therapeutic tool to treat autoimmune diseases and GVHD. This paper reviewed the immunomodulatory activity of MSC-EV as well as the research progress of MSC-EV in hematopoietic stem cell transplantation, and discussed its potential clinical applications in the future.

关 键 词：间充质干细胞 胞外囊泡 免疫调节 造血干细胞移植 

分 类 号：R457.7[医药卫生—治疗学]