酿酒酵母与哺乳动物的ODC1-OAZ1-AZIN1信号轴  

ODC1-OAZ1-AZIN1 signal axis in mammals and Saccharomyces cerevisiae

作　　者：陈志延 刘森 CHEN Zhiyan;LIU Sen(Key Laboratory of Fermentation Engineering(Ministry of Education)&National“111”Center for Cellular Regulation and Molecular Pharmaceutics,School of Bioengineering and Food,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学生物工程与食品学院,教育部发酵工程重点实验室/细胞调控与分子药物“111”引智基地,武汉430068

出　　处：《生命的化学》2022年第2期176-183,共8页Chemistry of Life

基　　金：国家自然科学基金项目(31971150);湖北省杰出青年基金项目(2019CFA069)。

摘　　要：多胺是一种普遍存在的必需脂肪族阳离子,对所有真核生物的生长、增殖、分化起着重要的作用。多胺代谢紊乱会对细胞生长造成严重的影响,靶向多胺代谢途径的关键酶成为治疗肿瘤的一个研究重点。酿酒酵母与哺乳动物在多胺调节方面存在一定的相似性,通过比对酿酒酵母与哺乳动物多胺调节的异同点,将有可能帮助我们更好地理解低等真核生物与高等真核生物的多胺调控差异。该文就酿酒酵母与哺乳动物的ODC1-OAZ1-AZIN1信号轴调控研究进展作一简要综述。Polyamines are ubiquitous essential aliphatic cations playing important roles in the growth,proliferation and differentiation of all eukaryotic cells.The dysregulation of polyamine metabolism has a serious impact on cell growth.Targeting the key enzymes in the polyamine metabolic network has become an important research area for tumor treatment.Saccharomyces cerevisiae and mammalian have certain similarities in the regulation of polyamine metabolism.By comparing the similarities and differences of the polyamine metabolic networks of the Saccharomyces cerevisiae and mammalian cells,we would gain better understanding in the regulation mechanism of polyamine regulation in eukaryotes.This paper reviews the recent research progresses of the ODC-OAZ1-AZIN1 signal axis in mammalian and Saccharomyces cerevisiae.

关 键 词：鸟氨酸脱羧酶 多胺调节 信号轴 

分 类 号：Q75[生物学—分子生物学]