细胞外基质在肿瘤发展及治疗中的作用  

Role of extracellular matrix in tumor development and therapy

作　　者：陈洁 陈众博[2] 张筠[2] 李莎[2] 虞亦鸣[2] CHEN Jie;CHEN Zhongbo;ZHANG Yun;LI Sha;YU Yiming(Ningbo University School of Medicine,Ningbo 315211,China;Affiliated Hospital of School of Medical of Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学院,宁波315211 [2]宁波大学医学院附属医院,宁波315211

出　　处：《生命的化学》2022年第3期385-393,共9页Chemistry of Life

基　　金：浙江省医药卫生科技计划项目(2016KYB268,2022RC247);宁波市自然科学基金项目(2018A610271,2017A60250);宁波市社会科学发展基金项目(2015C50012);宁波市青年骨干人才项目(2020SWSQNGG-05);宁波大学医学院附属医院青苗人才培育基金项目(FYQM-LC-202003)。

摘　　要：肿瘤细胞外基质作为肿瘤组织重要的组成部分,具有独特的物理、化学、生物特性。这些特性影响肿瘤的生物学行为。本文主要介绍了肿瘤细胞外基质的结构特点、肿瘤细胞外基质在肿瘤生长侵袭过程中的作用、针对肿瘤细胞外基质抗肿瘤治疗及肿瘤细胞外基质耐药的机制。了解肿瘤细胞外基质的这些特性,有利于临床上针对恶性肿瘤在物理学、生物化学、免疫学上的诊断方法的开发,同时为抗肿瘤治疗和提高抗肿瘤药物疗效提供了新思路。As an important part of tumor tissue,tumor extracellular matrix has unique physical,chemical and biological characteristics.These characteristics influence the biological behavior of tumors.This work mainly introduces the structural characteristics of tumor extracellular matrix,the role of tumor extracellular matrix in tumor growth and invasion process,anti-tumor therapy and the mechanisms of drug resistance.Understanding these characteristics of tumor extracellular matrix is beneficial to the development of physical,biochemical and immunological,diagnosis methods for malignant tumors in clinical,and provides new ideas for anti-tumor therapy and improving the efficacy of anti-tumor drugs.

关 键 词：细胞外基质 肿瘤 耐药性 抗肿瘤治疗 

分 类 号：R730[医药卫生—肿瘤]