磷脂酰胆碱的生物学功能及其在心血管疾病中的作用  

Biological function of phosphatidylcholine and its role in cardiovascular diseases

作　　者：姜月华[1] 陈健乔 李晓[1] 姜萍[1] 杨传华[1] JIANG Yuehua;CHEN Jianqiao;LI Xiao;JIANG Ping;YANG Chuanhua(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院,济南250014

出　　处：《生命的化学》2022年第3期412-423,共12页Chemistry of Life

基　　金：国家自然科学基金项目(81874449);国家自然科学基金项目(82174177)。

摘　　要：磷脂酰胆碱(phosphatidylcholine,PC)作为真核细胞膜结构的主要成分,是哺乳动物细胞中含量最丰富的磷脂,占细胞总磷脂的45%~55%。由于PC脂肪酰基链的长度和饱和度可进行修饰重塑,因此PC分子具有很大的多样性。本文回顾了PC的合成、分解、生物学功能及其在心血管疾病中的作用,分析了PC作为膜组分构成细胞和细胞器膜,参与脂蛋白的组装和分泌,以及作为信号分子和炎性介质的前体分子发挥多种生物学功能,在动脉粥样硬化、高血压、冠心病、心力衰竭等多种心血管疾病的发生发展过程中具有重要作用。Phosphatidylcholine(PC),as the main component of eukaryotic membrane structure,is the most abundant phospholipids in mammalian cells(45%~55%of the total phospholipids).Because the length and saturation of its fatty acyl chain can be modified and remodeled,PC molecules demonstrate great diversity.This paper reviewed the synthesis,decomposition,biological process of PCs and their roles in cardiovascular diseases.It is suggested that PCs not only constitute the cellular and organelle membrane as membrane components and participate in the assembly and secretion of lipoprotein,but also work as a precursor molecule of signal molecules and inflammatory mediators,so as to play an important role in the occurrence and development of atherosclerosis,hypertension,coronary heart disease,heart failure and other cardiovascular diseases.

关 键 词：磷脂酰胆碱 生物学功能 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]