多糖放射性同位素标记及其体内药动学应用的研究进展  

Polysaccharide Radioisotopic Labeling and Its Application in Pharmacokinetics Study In Vivo

作　　者：郑子明 张玉[1] 张琪琳[1] 罗立[1] 潘祥林 王凯平[2] ZHENG Zi-ming;ZHANG Yu;ZHANG Qi-lin;LUO Li;PAN Xiang-lin;WANG Kai-ping(Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation,Tongji Medical College of Pharmacy,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属协和医院药学部,武汉430030 [2]华中科技大学同济医学院药学院,武汉430030

出　　处：《中国药学杂志》2022年第8期599-604,共6页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82074111,82104282)。

摘　　要：多糖具有良好的药理活性和较低的毒副作用,关于天然多糖药理活性的报道也是层出不穷。随着对多糖理化性质研究的进一步深入,多糖作为生物材料也逐渐用于新制剂的开发。但是相较于多糖药理活性和作为生物材料的研究,多糖体内药动学的研究十分匮乏,这严重限制了多糖进一步的开发应用。目前,体外放射性同位素标记成为了多糖体内药动学研究的重要手段,本研究总结了用于多糖标记的各种放射性同位素,并分析了不同放射性同位素在多糖体内药动学研究中的特点,以及影响多糖药动学的因素和基于多糖体内药动学特征的应用。对多糖体内药动学的深入研究,能够为多糖作为药品和生物材料的开发提供重要的指导。Polysaccharides were widely developed as drugs or health care products due to their good pharmacological activities and low side effects.With the research on the physicochemical properties of polysaccharides,polysaccharides as biomaterials were gradually used in the development of new preparations.However,compared with the researches of polysaccharides on pharmacological activities and as biomaterials,their pharmacokinetics studies in vivo were obviously insufficient,which seriously limited the development of polysaccharides as drugs and biomaterials.At present,radioisotope labeling has become an important method for the study of polysaccharide pharmacokinetics in vivo.This paper summarizes various radioisotopes used for polysaccharide labeling,and analyzes the characteristics of different radioisotopes in the study of polysaccharide pharmacokinetics in vivo.Moreover,the factors influencing the pharmacokinetics of polysaccharides are analyzed,and the application based on the pharmacokinetics characteristics of polysaccharides in vivo is discussed.The in-depth study on the pharmacokinetics of polysaccharides in vivo could provide important guidance for the development of polysaccharides as drugs and biomaterials.

关 键 词：多糖 放射性同位素标记 药动学 

分 类 号：R969.1[医药卫生—药理学]