琥珀酸脱氢酶抑制剂(SDHI)类杀菌剂抗性机制研究进展  

Research progress on resistance mechanism of succinate dehydrogenase inhibitor(SDHI)fungicides

作　　者：赵平[1,2] 白雪婧 邓云艳[1] 赵英鹏 汪涛 纪明山 ZHAO Ping;BAI Xue-jing;DENG Yun-yan;ZHAO Ying-peng;WANG Tao;JI Ming-shan(College of Plant Protection,Shenyang Agricultural University,Shenyang 110866,China;Shenyang Sinochem Agrochemicals R&D Co.,Ltd.,Shenyang 110021,China;Liaoning Province Lvyuan Nongfeng Agricultural Technology Service Co.,Ltd.,Shenyang 110000,China;Shenyang Academy of Landscape-gardening,Shenyang 110016,China)

机构地区：[1]沈阳农业大学植物保护学院,沈阳110866 [2]沈阳中化农药化工研发有限公司,沈阳110021 [3]辽宁省绿源农丰农业技术服务有限公司,沈阳110000 [4]沈阳市园林科学研究院,沈阳110016

出　　处：《农药》2022年第6期391-395,405,共6页Agrochemicals

基　　金：贵州大学绿色农药与生物工程教育部重点实验室开放基金资助项目(2019GDGP0103)。

摘　　要：近年来,琥珀酸脱氢酶抑制剂(SDHI)类杀菌剂受到全球关注,因作用位点单一,使用广泛,该类杀菌剂的抗性问题日益突出,已被归为中等至高抗性风险杀菌剂。综述了该类杀菌剂的应用现状、抗性机制研究进展及交互抗性情况,该类杀菌剂的抗性机制和交互抗性与病原菌琥珀酸脱氢酶SDHB、SDHC、SDHD亚基上的位点突变有关,发生突变频率最高的是SDHB亚基,突变后的氨基酸降低了药剂与琥珀酸脱氢酶的结合能力,这也是抗性产生的主要原因。目前开发的大多数SDHI类杀菌剂均在同一交互抗性组,随着抗性的逐渐产生,未来可能有些品种还未上市便已产生抗性,这也为未来该类杀菌剂结构设计和抗性治理提出了巨大的挑战。In recent years,succinate dehydrogenase inhibitor(SDHI)fungicides have attracted global attention.Due to the single action site and wide use,the resistance problem of these fungicides has become increasingly prominent,and they have been classified as fungicides with moderate to high resistance risk.The application status,research progress of resistance mechanism and cross-resistance of fungicides were reviewed.The resistance mechanism and cross-resistance of fungicides were related to the mutation of SDHB,SDHC and SDHD subunits of succinate dehydrogenase,and the SDHB subunit had the highest mutation frequency.The mutated amino acid reduces the binding ability of the agent to succinate dehydrogenase,which is the main cause of resistance.Most SDHIs fungicides developed at present are in the same cross-resistance group.With the gradual emergence of resistance,some varieties may develop resistance before being marketed in the future,which also poses great challenges for the structural design and resistance management of such fungicides in the future.

关 键 词：琥珀酸脱氢酶抑制剂 抗性机制 交互抗性 研究进展 

分 类 号：TQ460[化学工程—制药化工]