卡贝缩宫素联合卡前列素氨丁三醇对高龄产妇二次剖宫产的产后出血防治效果  

Prevention and treatment effect of the combination of carbetocin and carboprosttromethamine on postpartum hemorrhage in women at advanced maternal age with the second cesarean section

作　　者：武红[1] WU Hong(Department of Obstetrics,The People's Hospital of Xintai City,Taian 271200,China)

机构地区：[1]新泰市人民医院产科,山东泰安271200

出　　处：《山东第一医科大学（山东省医学科学院）学报》2022年第6期442-445,共4页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

摘　　要：目的 探讨卡贝缩宫素与卡前列素氨丁三醇注射液联合应用对高龄产妇二次剖宫产的产后出血临床效果。方法 选择2020年10月—2021年10月在新泰市人民医院住院行二次剖宫产的高龄产妇82例作为研究对象,分为对照组与观察组,每组各41例,对照组应用卡前列素氨丁三醇注射液治疗,观察组在对照组的基础上联合卡贝缩宫素治疗,比较两组产妇术中、术后2 h、术后24 h出血量及产后出血发生率;产后24 h的血红蛋白,凝血指标变化;产后2h血压及心率的变化。结果 术中、术后2 h、术后24 h观察组产妇的出血量明显少于对照组,差异有统计学意义(P <0.05);观察组产后出血发生率少于对照组,差异有统计学意义(P <0.05);产后24 h血红蛋白数值下降观察组少于对照组,差异有统计学意义(P <0.05);血浆凝血酶原时间(prothrombin time,PT)及活化部分凝血活酶时间(activated partial thromboplastin time,APTT)数值变化比较,差异无统计学意义(P> 0.05);两组产前及术后2 h血压及心率的变化,观察组血压降低及心率的增加数值均少于对照组,差异有统计学意义(P <0.05)。结论 卡贝缩宫素与卡前列素氨丁三醇注射液联合应用于高龄产妇二次剖宫产术后,临床效果好,可减少产妇术中及术后的出血量,降低产后出血的发生。Objective:To investigate the clinical effect of the combination of carbetocin and carboprosttromethamine injection on postpartum hemorrhage in women at advanced maternal age with the second cesarean section. Methods:From October 2020 to October 2021,82 puerpera at advanced maternal age with the second cesarean section in our hospital were selected as the research subjects,and were randomly divided into the control group and the observation group,with 41 cases in each group. Patients in the control group was treated with carboprosttromethamine injection,and patients in the observation group was treated with carbetocin on the basis of the control group. The following parameters were compared between the two groups:bleeding volume and incidence of postpartum hemorrhage during operation,at 2 hours and 24 hours after operation;changes in hemoglobin and coagulation indexes at 24 hours after delivery;changes in blood pressure and heart rate at 2 hours after delivery. Results:The bleeding volume of puerpera in the observation group was significantly less than that in the control group(P < 0. 05)during operation,at 2 hours and 24 hours after operation. The incidence of postpartum hemorrhage in the observation group was less than that in the control group,with significant difference(P <0. 05). The hemoglobin decrease in the observation group was less than that in the control group at 24 hours after delivery,with significant difference(P < 0. 05). There was no significant difference in the changes of coagulation indexes of prothrombin time(PT)and activated partial thromboplastin time(APTT)(P > 0. 05). Regarding the changes of blood pressure and heart rate before and 2 hours after the operation in the two groups,the decrease in blood pressure and the increase in heart rate in the observation group were lower than those in the control group,and there was significant difference(P < 0. 05). Conclusion:The combination of carbetocin and carboprosttromethamine injection has a good clinical effect on women at advanced maternal age

关 键 词：卡贝缩宫素 卡前列素氨丁三醇 高龄产妇 二次剖宫产 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]