维生素K_(2)联合咪达普利在高血压合并骨质疏松患者中的应用效果  

Application effect of vitamin K_(2) combined with Midapril in patients with hypertension complicated with osteoporosis

作　　者：郑岩良 ZHENG Yanliang(Department of Endocrinology,Dalian Fourth People′s Hospital,Liaoning Province,Dalian116031,China)

机构地区：[1]大连市第四人民医院内分泌科,辽宁大连116031

出　　处：《中国当代医药》2022年第17期62-65,共4页China Modern Medicine

摘　　要：目的研究维生素K_(2)联合咪达普利对高血压合并骨质疏松患者的疗效及对25羟维生素D[25(OH)D_(3)]、β-Ⅰ型胶原羧基端肽(β-CTX)、骨钙素N端中分子片段(N-MID)水平的影响。方法选取2019年9月至2021年1月于大连市第四人民医院进行治疗的120例高血压合并骨质疏松患者作为研究对象,采用电脑随机法将其分为对照组(60例)和观察组(60例)。对照组患者采用咪达普利治疗,观察组患者在对照组的基础上联合应用维生素K_(2)。比较两组患者的疗效和满意度,记录两组患者治疗前后的25(OH)D_(3)、β-CTX、N-MID以及核因子-κB受体活化因子配体(RANKL)水平。结果观察组治疗后的总有效率为95.00%,高于对照组的81.67%,差异有统计学意义(P<0.05)。两组患者治疗后的25(OH)D_(3)水平均高于治疗前,而β-CTX水平低于治疗前,差异有统计学意义(P<0.05)。观察组治疗后的25(OH)D_(3)水平高于对照组,β-CTX水平低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的N-MID、RANKL水平均高于治疗前,差异有统计学意义(P<0.05)。观察组治疗后的N-MID,RANKL水平均高于对照组,差异有统计学意义(P<0.05)。观察组的总满意度高于对照组,差异有统计学意义(P<0.05)。结论高血压合并骨质疏松患者采用维生素K_(2)和咪达普利治疗可以有效提高其治疗效果,改善机体内的25(OH)D_(3)、β-CTX、N-MID以及RANKL水平。Objective To study the efficacy of vitamin K_(2) combined with Midapril in patients with hypertension complicated with osteoporosis and the influence on 25 hydroxy vitamin D[25(OH)D_(3)],beta C-terminal cross-linked telopeptides of typeⅠcollagen(β-CTX)and N-terminal-midfragment of osteocalcin(N-MID).Methods A total of 120 patients with hypertension and osteoporosis treated in Dalian Fourth People′s Hospital from September 2019 to January 2021 were selected as the research objects,they were divided into the control group(60 cases)and the observation group(60 cases)according to computer randomization.The control group was treated with Midapril,and the observation group was treated with combined vitamin K_(2) based on the control group.The efficacy and satisfaction of the two groups were compared,and the levels of 25(OH)D_(3) andβ-CTX,N-MID and receptor activator of nuclear factor-κB ligand(RANKL)before and after treatment in the two groups was recorded.Results The total effective rate in the observation group after treatment was 95.00%,which was higher than 81.67%in the control group,the difference was statistically significant(P<0.05).The 25(OH)D_(3) levels after treatment in the two groups were higher than those before treatment,theβ-CTX levels after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).The level of 25(OH)D_(3) in the observation group after treatment was higher than that in the control group,the level ofβ-CTX in the observation group after treatment was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of N-MID and RANKL after treatment in the two groups were higher than those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of N-MID and RANKL in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total satisfaction of the observation group was hi

关 键 词：维生素K_(2) 咪达普利 高血压 骨质疏松 25羟维生素D β-Ⅰ型胶原羧基端肽 骨钙素N端中分子片段 

分 类 号：R544.1[医药卫生—心血管疾病]