纳米银抗菌水凝胶敷料联合重组人碱性成纤维细胞生长因子对踝部开放骨折患者的治疗效果  

Therapeutic effect of nano-silver antibacterial hydrogel dressing combined with recombinant human basic fibroblast growth factor on patients with open ankle fracture

作　　者：张世纲 ZHANG Shigang(Department of Burn and Plastic Surgery,Shenyang Jishuitan Hospital,Liaoning Province,Shenyang110020,China)

机构地区：[1]沈阳积水潭医院烧伤整形科,辽宁沈阳110020

出　　处：《中国当代医药》2022年第17期85-88,共4页China Modern Medicine

摘　　要：目的研究纳米银抗菌水凝胶敷料(NSAHD)联合重组人碱性成纤维细胞生长因子(RHBFGF)对踝部开放骨折患者的治疗效果。方法选择2019年3月至2020年5月在沈阳积水潭医院进行治疗的100例踝部开放性骨折患者作为研究对象,依据随机数字表法分为对照组与观察组,每组各50例。对照组采用凡士林以及无菌纱布对创面进行敷盖,观察组采用NSAHD联合RHBFGF进行治疗,比较两组患者的创面愈合总有效率及丙二醛(MDA)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平。结果观察组患者治疗后的创面愈合总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的MDA水平低于本组治疗前,SOD水平高于本组治疗前,差异有统计学意义(P<0.05)。观察组患者治疗后的MDA水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的IL-6、CRP及TNF-α水平均低于本组治疗前,同时观察组患者治疗后的IL-6、CRP及TNF-α水平低于对照组,差异均有统计学意义(P<0.05)。结论踝部开放性骨折患者联合应用NSAHD和RHBFGF可以获得更好的疗效,同时能够改善机体的氧化应激状态及炎症反应。Objective To study the therapeutic effect of nano-silver antibacterial hydrogel dressing(NSAHD)combined with recombinant human basic fibroblast growth factor(RHBFGF)on patients with open ankle fracture.Methods A total of 100 patients with open ankle fractures treated in Shenyang Jishuitan Hospital from March 2019 to May 2020 were selected as research objects,they were divided into the control group and the observation group according to random number table method,with 50 cases in each group.The control group was treated with vaseline and sterile gauze,while the observation group was treated with NSAHD combined with RHBFGF.The total effective rate of wound healing,the levels of malondialdehyde(MDA),superoxide dismutase(SOD),interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)were compared between the two groups.Results The total effective rate of wound healing after treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of MDA in the two groups after treatment were lower than those before treatment,and the levels of SOD in the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The level of MDA in the observation group after treatment was lower than that in the control group,and the level of SOD in the observation group after treatment was higher than that in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,CRP and TNF-αin the two groups after treatment were lower than those before treatment,the levels of IL-6,CRP and TNF-αin the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of NSAHD and RHBFGF can achieve better effects in patients with open ankle fractures,and can improve oxidative stress and inflammation.

关 键 词：纳米银抗菌水凝胶敷料 重组人碱性成纤维 踝骨开放性骨折 创面愈合 

分 类 号：R683.42[医药卫生—骨科学]