持续性姿势-知觉性头晕相关因素的研究  

Study on influencing factors of persistent postural-perceptual dizziness

作　　者：吴跃华[1] 刘凯[1] WU Yue-hua;LIU Kai(Department of Emergency,Baotou Fourth Hospital,Baotou 014030,China)

机构地区：[1]内蒙古包头市第四医院急诊科,014030

出　　处：《中国实用医药》2022年第10期57-60,共4页China Practical Medicine

基　　金：包头市卫生基金(项目编号:wsjj2019065)。

摘　　要：目的 研究同型半胱氨酸(Hcy)、促甲状腺激素(TSH)水平和持续性姿势-知觉性头晕(PPPD)的关系。方法 选择60例PPPD患者作为PPPD组,同期40例健康者作为对照组。收集所有研究对象的相关资料,并使用酵素联免疫吸附试验检测Hcy、TSH、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)。分析发生PPPD的单因素,比较两组Hcy、FT3、FT4、TSH水平。结果 两组年龄、饮酒史、吸烟史、脑卒中家族史、高脂血症、糖尿病比较,差异无统计学意义(P>0.05)。PPPD组女性、高血压、失眠、焦虑、梅尼埃病史、良性突发性位置性眩晕史、前庭性偏头痛史占比高于对照组,差异有统计学意义(P<0.05)。PPPD组Hcy(19.66±6.49)μmol/L高于对照组的(14.65±4.58)μmol/L,差异具有统计学意义(P<0.05)。PPPD组FT3(2.34±0.89)pg/ml、FT4(4.06±1.79)pg/ml低于对照组的(3.54±0.79)、(7.29±2.16)pg/ml,TSH(6.36±2.59)μIU/ml高于对照组的(2.49±1.05)μIU/ml,差异有统计学意义(P<0.05)。结论 女性、高血压、失眠、焦虑、梅尼埃病史、良性阵发性位置性眩晕史、前庭性偏头痛史、Hcy水平上升、甲状腺功能减退与PPPD发生有关联。Objective To study the correlation between homocysteine(Hcy),thyroid stimulating hormone(TSH) and persistent postural-perceptual dizziness(PPPD).Methods 60 PPPD patients were selected as PPPD group,and 40 healthy subjects during the same period were selected as the control group.Relevant data of all subjects were collected,and enzyme-linked immunosorbent assay was used to detect Hcy,TSH,free triiodothyronine(FT3),and free thyroxine(FT4).The single factor of PPPD was analyzed,and the levels of Hcy,FT3,FT4 and TSH were compared between the two groups.Results There was no statistically significant difference in age,history of alcohol consumption,smoking history,family history of stroke,hyperlipidemia,and diabetes mellitus between the two groups(P>0.05).The proportions of female,hypertension,insomnia,anxiety,Meniere’s disease history,history of benign paroxysmal positional vertigo,history of vestibular migraine in the PPPD group were higher than those in the control group,and the difference was statistically significant(P<0.05).The Hcy(19.66±6.49) μmol/L in the PPPD group was higher than(14.65±4.58) μmol/L in the control group,and the difference was statistically significant(P<0.05).In PPPD group,the FT3(2.34±0.89) pg/ml and FT4(4.06±1.79) pg/ml in PPPD group were lower than(3.54±0.79) and(7.29±2.16) pg/ml in the control group,and the TSH(6.36±2.59) μIU/ml was higher than(2.49±1.05) μIU/ml in the control group.All the differences were statistically significant(P<0.05).Conclusion Female,hypertension,insomnia,anxiety,Meniere’s disease history,benign paroxysmal positional vertigo,history of vestibular migraine,elevated Hcy level and hypothyroidism are associated with PPPD.

关 键 词：持续性姿势-知觉性头晕 同型半胱氨酸 促甲状腺激素 因素 

分 类 号：R441.2[医药卫生—诊断学]