比格犬股骨大段骨缺损髓内钉固定方案设计的三维有限元建模分析  

Three-dimensional finite element model analysis of intramedullary nailing fixation design for large femoral defects in Beagle dogs

作　　者：温星花 丁焕文[1,2] 成凯 闫晓楠 彭元昊 王宇宁 刘康 张挥武[3] Wen Xinghua;Ding Huanwen;Cheng Kai;Yan Xiaonan;Peng Yuanhao;Wang Yuning;Liu Kang;Zhang Huiwu(South China University of Technology,Guangzhou 510641,Guangdong Province,China;Guangzhou First People’s Hospital,Guangzhou 510180,Guangdong Province,China;Sichuan Orthopedic Hospital,Chengdu 610041,Sichuan Province,China)

机构地区：[1]华南理工大学,广东省广州市510641 [2]广州市第一人民医院,广东省广州市510180 [3]四川省骨科医院,四川省成都市610041

出　　处：《中国组织工程研究》2023年第9期1371-1376,共6页Chinese Journal of Tissue Engineering Research

基　　金：广东省基础与应用基础研究基金项目(2021A1515012564),项目负责人:丁焕文;广州市科技计划项目(202007020002),项目参与人:丁焕文;四川省科技计划项目(2019YFS0446),张挥武。

摘　　要：背景:大段骨缺损现象时有发生,但目前假体如何设计尚由医生主观经验判断,有限元分析的出现有望改变这一局面,可以为临床医师实施手术提供技术支持,提高手术治愈率。目的:利用有限元分析研究植入体及髓内钉设计方案对比格犬大段骨缺损修复手术的影响。方法:基于比格犬CT图像数据建立其正常左侧股骨的三维模型。在此基础上建立大段骨缺损三维有限元模型,分别从锁钉粗细、锁钉数量、植入体长度及锁钉距截面中心的距离等方面,建立4组12个不同的实验模型(每组3个模型),通过有限元仿真分析,探讨术后髓内钉的力学结构特性,对比分析各模型的生物力学效果,得到最佳的设计方案。结果与结论:(1)第一组实验,锁钉直径为2.7 mm时,髓内钉应力最大值较其他2种模型小;(2)第二组实验,锁钉数量为4根时,髓内钉应力最大值较其他2种模型小;(3)第三组实验,植入体长度为20 mm时,髓内钉应力最大值较其他2种模型小;(4)第四组实验,锁钉距截面中心距离为30 mm时,髓内钉应力最大值较其他2种模型小;(5)提示髓内钉大小确定后,锁钉直径应选取髓内钉直径的一半左右为最佳,锁钉数量为4根、上下均2根为最佳,植入体长度应越短越好,锁钉距截面中心的距离尽可能远一点。BACKGROUND:Large bone defects occur from time to time,but at present,how to design the prosthesis is still judged by doctors’ subjective experience.The appearance of finite element analysis is expected to change this situation,provide the technical suppo rt for clinicians to carry out surgery,and improve the recovery rate of the surgery.OBJECTIVE:To investigate the effects of implant and intramedullary nail design project on repair of large bone defects in Beagle dogs by finite element analysis.METHODS:The 3 D model of the normal left femur was established based on the CT image data of Beagle dogs.Large bone defect three-dimensional finite element model was set up,from the thickness and quantity of locking nail,the length of the implants and the distance from the center of cross section to locking nail.Four groups of 12 different experimental models(three models per group) were esta blished.Through the finite element analysis,we studied the mechanical and structu ral characteristics of intramedulla ry nails after operation,compared biomechanical effects of each model,and obtained the best design scheme.RESULTS AND CONCLUSION:(1) In the first group,when the locking nail diameter was 2.7 mm,the maximum stress of intramedullary nails was the smallest compared with the other two groups.(2) In the second group,when the number of nails was four,the maximum stress of intramedulla ry nails was the smallest compared with the other two groups.(3) In the third group,when the length of the implant was 20 mm,the maximum stress of the intramedullary nail was the smallest compared with the other two groups.(4) In the fourth group,when the distance from the nail to the center of the cross section was 30 mm,the maximum stress of the intramedullary nail was the smallest compared with the other two groups.(5) These results verify that after the size of the intramedulla ry nail is determined,the diameter of the locking nail should be about half of the diameter of the intramedullary nail,and the number of the nail should be four,wi

关 键 词：大段骨缺损 植入体 髓内钉 生物力学 有限元分析 比格犬 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R687