镇肝熄风汤治疗肝阳上亢型高血压临床研究  

Clinical Study on Liver-Sedating and Wind-Extinguishing Decoction in the Treatment of Hypertension with Hyperactivity of Liver Yang

作　　者：刘璐 LIU Lu(Xiyuzhuang Street Community Health Service Center of Hongqiao District of Tianjin,Tianjin,China,300130)

机构地区：[1]天津市红桥区西于庄街社区卫生服务中心,天津300130

出　　处：《河南中医》2022年第8期1222-1225,共4页Henan Traditional Chinese Medicine

基　　金：天津市中医药科技计划项目(2018A0319)。

摘　　要：目的:观察镇肝熄风汤治疗肝阳上亢型高血压的临床疗效。方法:将120例肝阳上亢型高血压患者按照随机数字表法分为观察组和对照组,每组各60例。对照组给予卡托普利治疗,观察组给予镇肝熄风汤治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、血压监测情况[24 h平均收缩压(24 h systolic blood pressure,24 h SBP)、24 h平均舒张压(24 h diastolic blood pressure,24 h DBP)、24 h平均收缩压变异系数(24 h systolic blood pressure variability,24 h SBPV)、24 h平均舒张压变异系数(24 h diastolic blood pressure variability,24 h DBPV)]。结果:观察组有效率为98.3%,对照组有效率为81.7%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后24 h SBP、24 h DBP、24 h SBPV、24 h DBPV均明显低于治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:镇肝熄风汤可明显降低肝阳上亢型高血压患者血压水平,改善患者临床症状,且临床安全性较好。Objective:To observe the clinical efficacy of Liver-Sedating and Wind-Extinguishing Decoction on hypertension with hyperactivity of liver yang.Methods:A total of 120 patients with hypertension of hyperactivity of liver yang were randomly divided into the observation group and the control group,with 60 cases in each group.The control group was treated with captopril,while the observation group was treated with Liver-Sedating and Wind-Extinguishing Decoction.The clinical efficacy,the changes of TCM syndrome score,and blood pressure monitoring [24 h mean systolic blood pressure(24 h SBP),24 h mean diastolic blood pressure(24 h DBP),24 h mean systolic blood pressure variability(24 h SBPV),24 h mean diastolic blood pressure variability(24 h DBPV)] and the incidence of adverse reactions before and after treatment were compared between the two groups.Results:The effective rate was 98.3% in the observation group and 81.7% in the control group.There was significant difference between the two groups(P<0.05).The TCM syndrome score of the two groups after treatment was lower than that of the group before treatment,and that of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).The 24 h SBP,24 h DPB,24 h SBPV and 24 h DBPV of the two groups after treatment were significantly lower than those before treatment,and all the differences between the two groups after treatment were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Liver-Sedating and Wind-Extinguishing Decoction can significantly reduce the blood pressure level of hypertension patients with hyperactivity of liver yang,improve their clinical symptoms,and has good clinical safety.

关 键 词：高血压 肝阳上亢证 镇肝熄风汤 卡托普利 

分 类 号：R259.441[医药卫生—中西医结合]