卡贝缩宫素联合卡前列素氨丁三醇治疗宫缩乏力所致产后出血的应用分析  

Analysis on Application of Carbetocin Combined with Carboprost Tromethamine in Treatment of Postpartum Hemorrhage Caused by Uterine Inertia

作　　者：孔丽娟 Kong Li-juan(Department of Obstetrics and Gynecology,Hui County People's Hospital,Longnan 742300,Gansu Province,China)

机构地区：[1]甘肃陇南市徽县人民医院妇产科,甘肃陇南742300

出　　处：《中国社区医师》2022年第16期51-53,共3页Chinese Community Doctors

摘　　要：目的:探讨卡贝缩宫素联合卡前列素氨丁三醇在宫缩乏力所致产后出血的应用效果。方法:收集2017年1月-2021年8月徽县人民医院治疗的100例宫缩乏力产后出血患者,随机分成观察组和对照组,各50例。对照组采取当产妇顺利娩出婴儿后,给予卡贝缩宫素静脉滴注,100μg/次,若止血不彻底,静脉滴注100μg。观察组在对照组的基础上于宫体注射卡前列素氨丁三醇250μg,术后2 h再注射1次。结果:观察组在术中出血量、产后2 h出血量高于对照组,产后24 h出血量低于对照组,差异有统计学意义(P<0.05)。观察组止血时间、术后血红蛋白指标均优于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组活化部分凝血活酶时间、凝血酶原时间及纤维蛋白原水平优于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:卡贝缩宫素联合卡前列素氨丁三醇治疗宫缩乏力所致产后出血止血快,不良反应少,疗效显著,值得推广。Objective: To investigate the application effect of carbetocin combined with carboprost tromethamine on postpartum hemorrhage caused by uterine inertia. Methods: A total of 100 patients with uterine inertia and postpartum hemorrhage who were treated in Hui County People’s Hospital from January 2017 to August 2021 were collected and randomly divided into observation group and control group, with 50 cases in each group. The control group was given intravenous infusion of carbetocin 100 μg/time after delivery, if hemostasis was not complete, intravenous infusion of 100 μg was given. The observation group was injected with carboprost tromethamine 250 μg into the uterus on the basis of control group, and an injection was given again at 2 h after operation. Results: The intraoperative blood loss and 2 h postpartum blood loss in the observation group were higher than those in the control group, and 24 h postpartum blood loss was lower than that in the control group, with statistically significant difference(P<0.05). The hemostatic time and postoperative hemoglobin indicator of the observation group were better than those of the control group, with statistically significant difference(P<0.05). After treatment, the activated partial thrombin time, prothrombin time and fibrinogen of the observation group were better than those of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in observation group was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion: The combination of carbetocin combined with carboprost tromethamine has rapid hemostasis, less adverse reactions and significant efficacy in treatment of postpartum hemorrhage caused by uterine inertia, which is worth promoting.

关 键 词：卡贝缩宫素 卡前列素氨丁三醇 子宫收缩乏力 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]