成纤维细胞生长因子21在脓毒症中的研究进展  

Research progress of fibroblast growth factor 21 in sepsis

作　　者：胡元慧 李欢[1] 汤冬玲[1] 张平安[1] HU Yuanhui;LI Huan;TANG Dongling;ZHANG Ping’an(Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《生命的化学》2022年第4期720-726,共7页Chemistry of Life

基　　金：国家自然科学基金项目(81773444)。

摘　　要：脓毒症是由机体对感染反应失调引起的危及生命的器官功能障碍,是危重病人死亡的重要原因。脓毒症的发生和预后常受病理性代谢紊乱的影响。成纤维细胞生长因子21(fibroblast growth factor21,FGF21)是FGF家族中的一种多肽激素,是调节糖脂代谢的关键因子,可在炎症和脓毒症中发挥重要作用。本文通过对FGF21的生物学特性、在脓毒症发病机制中的作用以及FGF21与脓毒症的临床关系进行综述,为FGF21在脓毒症诊治与预后的转化中的应用提供依据。Sepsis is a life-threatening organ dysfunction caused by the body’s unbalanced response to infection,and it often causes death of critically ill patients.The occurrence and prognosis of sepsis are often affected by pathological metabolic disorders.Fibroblast growth factor 21(FGF21) is a polypeptide hormone in the FGF family.It is a key factor regulating glucose and lipid metabolism and can play an important role in inflammation and sepsis.This paper reviews the biological characteristics of FGF21,the role of FGF21 in the pathogenesis of sepsis,and the clinical relationship between FGF21 and sepsis,and provides a basis for the transformation and application of FGF21 in the diagnosis,treatment and prognosis of sepsis.

关 键 词：脓毒症 成纤维细胞生长因子21 诊治 预后 

分 类 号：R459.7[医药卫生—急诊医学]