肌源性microRNA-133的研究进展  

Research progress in myogenic microRNA-133

作　　者：郭兰兰 邢正[2] 张玉寒 张靓 GUO Lanlan;XING Zheng;ZHANG Yuhan;ZHANG Jing(Department of Physical Education,University of International Business and Economics,Beijing 100029,China;School of Physical Education and Sports,Beijing Normal University,Beijing 100875,China)

机构地区：[1]对外经济贸易大学体育部,北京100029 [2]北京师范大学体育与运动学院,北京100875

出　　处：《生命的化学》2022年第4期727-736,共10页Chemistry of Life

基　　金：国家自然科学基金项目(31871207);对外经济贸易大学青年项目(14QN06)。

摘　　要：MicroRNA-133属内源性非编码microRNA家族成员之一,主要在骨骼肌和心肌中表达,因此也被称为肌源性miRNA(myomiR)。肌源性miR-133通过其丰富的生物学功能在多种疾病调控过程中发挥重要的病理生理作用。运动通过调节骨骼肌来源的miR-133表达,可能是运动防治慢性疾病的重要机制之一。本文将根据国内外研究进展对肌源性miR-133的生物学功能、病理生理意义及运动对miR-133的调节作用等进行综述。MicroRNA-133 is a member of endogenous non coding miRNA family,which is mainly expressed in skeletal muscle and myocardium,also known as myogenic miRNA(myomiR).Myogenic miR-133 is closely related to the occurrence and development of many diseases through its rich biological functions.Exercise can regulate the expression of skeletal muscle derived miR-133 to promote the crosstalk between skeletal muscle and other tissues,which may be one of the essential mechanisms for exercise prevents chronic diseases.In this review,we will reveal the biological function,pathophysiological significance of myogenic miR-133 and the regulation of exercise on miR-133 according to the research progress.

关 键 词：肌源性miR-133 生物学功能 病理生理作用 运动 

分 类 号：Q522[生物学—生物化学]