NLRP3 inflammasome activation is involved in manganeseinduced immunotoxicity  

作　　者：Jing Ji Haiyi Yu Lei Liao Jiaojiao Li Kunming Qin Jinyang Shen Bo Guo Xiaofu Shao Jinming Ma Jingquan Dong Song Gao 

机构地区：[1]Jiangsu Key Laboratory of Marine Biological Resources and Environment,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Co-Innovation Center of Jiangsu Marine Bio-industry Technology,School of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,China

出　　处：《Acta Biochimica et Biophysica Sinica》2022年第2期271-274,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.31470275);the Key Natural Science Research Project of the Jiangsu Higher Education Institutions of China(No.20KJA416002);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.20KJB350008);the Science and Technology Project of Lianyungang High-tech Zone of China(No.HZ201901);the Open-end Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202004);the“Blue Project”of Jiangsu Higher Education Institutions of China,and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

摘　　要：Manganese(Mn)is an essential trace element for the normal development of human body.It plays an important role in the regulation of cellular energy level,blood sugar balance,function of immunity,and bone growth,and works as an essential part of many indispensable enzyme functions.Meanwhile,overexposure to divalent manganese(Mn2+)could cause a series of physiological and pathological dysfunctions,and Mn has been recognized as an environmental toxicant and an occupational hazard[1].With the increasing exposure risk in environmental settings,such as contaminated food and polluted water and soil,Mn2+-induced toxicities have become an important public health issue.

关 键 词：functions MANGANESE ACTIVATION 

分 类 号：O62[理学—有机化学]