中性粒细胞胞外诱捕网(NET)对血液系统疾病的免疫调节作用  

The immunomodulatory effect of neutrophil extracellular trapping nets(NETs)on hematological diseases

作　　者：黄梅 王诗雨 郝正栋[1] 郭晓嘉[1] 楚松林 李莉娟[1] 张连生[1] HUANG Mei;WANG Shiyu;HAO Zhengdong;GUO Xiaojia;CHU Songlin;LI Lijuan;ZHANG Liansheng(Department of Hematology,Lanzhou University Second Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院血液科,甘肃兰州730000

出　　处：《细胞与分子免疫学杂志》2022年第4期374-377,共4页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金地区科学基金(31660112);兰州大学萃英科技创新计划重点培育项目(CY2017-ZD04);兰州大学萃英科技创新计划应用基础研究项目(CY2019-MS14)。

摘　　要：中性粒细胞胞外诱捕网(NET)是中性粒细胞产生的由染色质DNA和蛋白质组成的一种细胞外纤维网状结构。NET可通过依赖NADPH的中性粒细胞胞外诱捕网凋零(NETosis)与不依赖NADPH的NETosis两条途径形成,形成后除了被血浆中DNA酶水解外,还可被巨噬细胞和树突状细胞进行胞内和胞外降解。随着近年来对NET的研究发现,在多种血液系统疾病NET表达增加,NET对血液系统疾病发挥着免疫调节作用,如NET与白血病治疗相关的感染密切相关,从而影响白血病的治疗及预后;NET参与多发性骨髓瘤的疾病进展、促进弥漫性大B细胞淋巴瘤的进展以及介导慢性骨髓增殖性肿瘤的血栓事件。Neutrophil extracellular traps(NETs)are characterized by a extracellular fibrous network structure produced by neutrophils with DNA and proteins.NETs can be formed by NADPH-dependent NETosis and NADPH-independent NETosis.After formation,it is not only hydrolyzed by DNase in plasma but can also be degraded intracellularly and extracellularly by macrophages and dendritic cells.Recent researches on NETs have reported the increased expression of NETs in a variety of hematological diseases and its immunomodulatory effect on blood system diseases.For example,NETs are closely linked to infections related to leukemia treatment,which affects the treatment and prognosis of leukemia;NETs are also involved in the progression of multiple myeloma,promote the progression of diffuse large B-cell lymphoma,and mediate the thrombotic events of chronic myeloproliferative tumors.

关 键 词：中性粒细胞胞外诱捕网(NET) 免疫调节 血液系统疾病 综述 

分 类 号：R392[医药卫生—免疫学] R552[医药卫生—基础医学] R825.5[文化科学—情报学] G353.11