基质金属蛋白酶对结核肉芽肿形成及免疫调控作用的研究进展  

Progress in effects of matrix metalloproteinases on formation and immune regulation of tuberculous granuloma

作　　者：刘莉 马沁梅 于嘉霖 邓光存 吴晓玲 LIU Li;MA Qin-mei;YU Jia-lin;DENG Guang-cun;WU Xiao-ling(Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western Chi-na,School of Life Sciences,Ningxia University,Yinchuan 750021,China)

机构地区：[1]西部特色生物资源保护与利用教育部重点实验室,宁夏大学生命科学学院,宁夏银川750021

出　　处：《中国病理生理杂志》2022年第6期1113-1119,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.32060160);宁夏重点研发计划项目(No.2018BFH03017)。

摘　　要：结核病(tuberculosis,TB)是由结核分枝杆菌(Mycobacterium tuberculosis,Mtb)感染引起的具有高致病性及死亡率的人畜共患传染病。作为一种胞内致病菌,Mtb通过气溶胶等途径感染肺部,随后被驻留在肺泡中的巨噬细胞识别、吞噬并发生复杂的相互作用。一方面,当Mtb感染巨噬细胞时。Tuberculosis(TB)is a zoonotic disease caused by Mycobacterium tuberculosis(Mtb)infection.The interaction between Mtb and the host immune system induces varieties of pathological changes in the lung. Granuloma is one of the main pathological features of TB with considerably complicated formation process. Matrix metalloproteinases(MMPs),a kind of secreted endopeptidases,are involved in the formation and immune regulation of pulmonary granulomas. Of note,MMPs participate in the immune regulation after Mtb infection,and the expression of MMPs is usually regulated by mitogen-activated protein kinases. MMPs modulate the inflammatory response in TB granuloma,and their expression affects the pathological changes of pulmonary granulomas after infection with Mtb. Inhibition of MMPs significantly reduces the granuloma formation. Inhibitors of MMPs used in the treatment of TB still need further exploration. Herein,this paper aims to provide theoretical basis for MMPs in the treatment of TB.

关 键 词：结核分枝杆菌 肉芽肿 基质金属蛋白酶 

分 类 号：R473.52[医药卫生—护理学] R363.21[医药卫生—临床医学]