能量代谢紊乱在高原心脏病发生过程中的作用  

Role of energy metabolism disorder in development of high-altitude heart disease

作　　者：韩艺玮 张致英 郝美莉 张晓英 HAN Yi-wei;ZHANG Zhi-ying;HAO Mei-li;ZHANG Xiao-ying(School of Medicine,Xizang Minzu University,Engineering Research Center of Tibetan Medicine Detection Technology,Ministry of Education,Xianyang 712082,China)

机构地区：[1]西藏民族大学医学院,西藏民族大学藏药检测技术教育部工程研究中心,陕西咸阳712082

出　　处：《中国病理生理杂志》2022年第6期1135-1141,共7页Chinese Journal of Pathophysiology

基　　金：西藏自治区自然科学基金项目[No.XZ2018ZRG-85(Z)];陕西省教育厅专项科学研究计划(No.19JK0890);西藏民族大学重大项目培育计划(No.18MDZ03,No.20MDT03);西藏自治区自然科学基金资助项目(No.XZ202001ZR0089G)。

摘　　要：高原地区具有海拔高(≥3 000 m以上)、气压低、氧分压低的特点,易导致机体缺氧从而引发一系列急、慢性高原病,如急性肺水肿、高原红细胞增多症、缺氧性脑水肿、急慢性高原心脏病(high-altitude heartdisease,HAHD)等,给高原地区居民人们的身心健康带来严重危害。其中慢性HAHD发病率高,危害大.High-altitude heart disease(HAHD)is a chronic progressive disease characterized by pulmonary arterial hypertension(PAH)and right ventricular hypertrophy(RVH)or right heart dysfunction caused by low pressure and hypoxia. As the main pathological feature of HAHD,RVH can be caused by oxidative stress,inflammation,fibrosis,energy metabolism disorder and other mechanisms. Energy metabolism disorder,as one of the pathogenic factors of PAH and RVH,has attracted much attention in recent years. As transcriptional regulatory factors affecting energy metabolism,hypoxia-inducible factor 1α(HIF-1α)and peroxisome proliferator-activated receptor α(PPARα)are involved in the regulation of PDK,PFKFB3,Kv,NDUFA4L2,miRNAs,KLF5,SIRT3,FOXO1 and other factors to promote the development of HAHD. In this paper,we review the research progress of the role of HIF-1α and PPARα/γ in HAHD.

关 键 词：高原心脏病 动脉型肺动脉高压 右心室肥厚 能量代谢紊乱 缺氧诱导因子1Α 过氧化物酶体增殖物激活受体 

分 类 号：R541.9[医药卫生—心血管疾病] R363.2[医药卫生—内科学]