Advanced tools and methods for single-cell surgery  

作　　者：Adnan Shakoor Wendi Gao Libo Zhao Zhuangde Jiang Dong Sun 

机构地区：[1]Department of Biomedical Engineering,City University of Hong Kong,Hong Kong,China [2]State Key Laboratory for Manufacturing Systems Engineering,International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies,The School of Mechanical Engineering,Xi'an Jiaotong University,Xi'an,China

出　　处：《Microsystems & Nanoengineering》2022年第2期1-21,共21页微系统与纳米工程（英文）

基　　金：supported by grants from the Hong Kong Research Grants Council(Ref.nos.Cl 134-20G and 11211421);the Shenzhen Science and Technology Project,China(Ref no SGDX2020110309300502);the National Science Foundation of China(Ref.no 52105589);the RGC Postdoctoral Fellowship Scheme(PDFS)(Ref.no PDFS2021-1S05).

摘　　要：Highly precise micromanipulation tools that can manipulate and interrogate cell organelles and components must be developed to support the rapid development of new cell-based medical therapies,thereby facilitating in-depth understanding of cell dynamics,cell component functions,and disease mechanisms.This paper presents a literature review on micro/nanomanipulation tools and their control methods for single-cell surgery.Micromanipulation methods specifically based on laser,microneedle,and untethered micro/nanotools are presented in detail.The limitations of these techniques are also discussed.The biological significance and clinical applications of single-cell surgery are also addressed in this paper.

关 键 词：MANIPULATION SURGERY NEEDLE 

分 类 号：Q2[生物学—细胞生物学]