泻火养阴方对中风(火热证)后尿失禁患者的疗效及血清LOX-1的影响  

Effect of Xiehuo Yangyin Recipe on the Curative Effect and Serum LOX-1 in Patients with Urinary Incontinence After Stroke(Fire-heat Syndrome)

作　　者：吴永惠 卢玉新 WU Yonghui;LU Yuxin(Internal Medicine Clinic of Hedong District Hospital of Traditional Chinese Medicine,Tianjin 300160,China)

机构地区：[1]天津市河东区中医院内科门诊,天津300160

出　　处：《中国药物滥用防治杂志》2022年第5期650-654,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨泻火养阴方治疗中风(火热证)后尿失禁患者的疗效及对血清凝集素样氧化低密度脂蛋白受体(LOX-1)的影响。方法:选取我院在2020年11月—2021年10月收治的60例中风后尿失禁患者作为研究对象,随机分成常规组与试验组,每组30例。常规组给予常规西药进行治疗,试验组在常规组基础上给予自拟泻火养阴方治疗,比较两组临床疗效、中医证候积分、排尿功能及控尿能力、血清LOX-1及药物不良反应。结果:治疗后,试验组总有效率为96.66%,高于常规组的73.33%(P<0.05);试验组小便失禁或频率、量多色清、头晕耳鸣、腰膝酸软等中医证候积分低于常规组(P<0.05);试验组贮尿期膀胱压力、排尿期膀胱压力、膀胱残余尿量、尿流率及全天排尿频率优于常规组(P<0.05);试验组LOX-1、MMP-9水平低于常规组(P<0.05);试验组不良反应率均低于常规组(P<0.05)。结论:泻火养阴方治疗中风(火热证)后尿失禁患者的疗效显著,可减轻临床症状,有效提升膀胱功能,优化血清LOX-1、MMP-9水平,安全性高。Objective: To investigate the efficacy of Xiehuo Yangyin Decoction in the treatment of urinary incontinence after stroke(fire-heat syndrome) and its influence on serum lectin-like oxidized low-density lipoprotein receptor(LOX-1). Methods: A total of 60 patients with urinary incontinence after stroke admitted to our hospital from November 2020to October 2021 were randomly divided into routine group and experimental group, with 30 cases in each group. The conventional group was treated with conventional western medicine, and the experimental group was treated with selfmade Xiehuo Yangyin prescription on the basis of the conventional group. The clinical efficacy, TCM syndrome score,urination function, urinary control ability, serum LOX-1 and adverse drug reactions were compared between the two groups.Results: After treatment, the total effective rate of the experimental group was 96.66%, which was higher than 73.33% of the conventional group(P<0.05). The scores of urinary incontinence or frequency, polychromaticity, dizziness, tinnitus, soreness and weakness of waist and knee in the experimental group were lower than those in the conventional group(P<0.05). The bladder pressure during urine storage, bladder pressure during urination, bladder residual urine volume, urinary flow rate and all-day urination frequency in the experimental group were better than those in the conventional group(P<0.05). The levels of LOX-1 and MMP-9 in the experimental group were lower than those in the conventional group(P<0.05). The adverse reaction rate of the experimental group was lower than that of the conventional group(P<0.05). Conclusion: The therapeutic effect of Xiehuo Yangyin Decoction on urinary incontinence after stroke(fire-heat syndrome) is remarkable, which can reduce clinical symptoms, effectively improve bladder function, optimize serum LOX-1 and MMP-9 levels, and has high safety.

关 键 词：中风 尿失禁 泻火养阴方 血清凝集素样氧化低密度脂蛋白受体(LOX-1) 不良反应 

分 类 号：R255.2[医药卫生—中医内科学]