特发性青少年骨质疏松症研究进展  

Research progress in idiopathic juvenile osteoporosis

作　　者：马燕华 王覃[1] 李静[1] 卢春燕[1] 陈德才[1] MA Yanhua;WANG Qin;LI Jing;LU Chunyan;CHEN Decai(Department of Endocrinology and Metabolism,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院内分泌代谢科,四川成都610041

出　　处：《中国骨质疏松杂志》2022年第6期916-921,共6页Chinese Journal of Osteoporosis

摘　　要：特发性青少年骨质疏松症(idiopathic juvenile osteoporosis,IJO)是一种罕见的、具有自限性的,以青春期早期全身骨痛、骨折、行走困难为主要表现的全身性骨病,大部分患者的症状可随青春期发育而自发缓解。目前病因尚不清楚,影像学表现为全身骨骼骨密度下降,容易出现腰椎椎体及长骨尤其干骺端骨折,“新生骨骨质疏松症”是其独特的影像学表现,其诊断需先排除其他常见的青少年降低骨密度原因。目前其药物治疗规范尚未达成共识,以补充钙剂、维生素D及双膦酸盐为主要治疗措施。大部分患者预后较好,极少部分遗留严重残疾。笔者就近年来特发性青少年骨质疏松症的发病机制、临床表现、影像学特点、诊治等方面的最新进展作一综述。Idiopathic juvenile osteoporosis(IJO)is a rare and self-limited systemic bone disease characterized by systemic bone pain,fractures,and difficulty walking in early adolescence,which spontaneously resolves in most patients as puberty develops.The etiology of the disease remains unknown.The imaging manifestations show a decrease in bone mineral density in the whole body,and fractures in the lumbar vertebra and long bones,especially in the metaphyseal region.The osteoporosis in new bones is its unique imaging manifestations.The diagnosis is based on the exclusion of other common causes of adolescent osteoporosis.At present,there is no consensus on the drug therapy standard.Supplement of calcium and vitamin D and the use of bisphosphonates are the main treatment measure.The majority of patients have a good prognosis,but a few are left with severe disability.This article reviews the recent advances in the pathogenesis,clinical manifestations,imaging features,diagnosis,and treatment of IJO.

关 键 词：特发性青少年骨质疏松症 发病机制 诊断 治疗 

分 类 号：R589.5[医药卫生—内分泌]