Fonsecaea monophora所致着色芽生菌病1例  

A case of cutaneous chromoblastomycosis caused by Fonsecaea monophora

作　　者：刘瑞真 陈静 徐明 卢万丁 LIU Ruizhen;CHEN Jing;XU Ming;LU Wanding(Dermatology Hospital of Fuzhou, Fuzhou 36000, China)

机构地区：[1]福州市皮肤病防治院,福州360000

出　　处：《中国真菌学杂志》2022年第3期225-226,共2页Chinese Journal of Mycology

摘　　要：患者,男,63岁,因“左手腕结节斑块半个月”为主诉就诊我科门诊。左手腕肥厚性的肉色斑块,结节,表面疣状增生,病理活检见真皮及多核巨细胞胞浆内褐色厚壁圆形硬壳小体。PAS染色(+),真菌培养见暗棕至黑色菌落生长;经测序,最终确诊为Fonsecaea monophora所致着色芽生菌病。予口服伊曲康唑治疗,但由于患者原发矽肺症状加重,后因矽肺引发并发症死亡。A 63-year-old male presented with a nodule on the left wrist for half a month.Physical examination showed hyperkeratotic plaques and nodule on the left wrist.Histopathological examination revealed a number of brown and roundish thick-walled sclerotic bodies in dermis and multinucleated giant cells.PAS staining was positive.Fungus culture test observed dark-brown to dark fungi which was confirmed as Fonsecaea monophora by sequencing.The patient was treated with oral itraconazole,but finally died of complications of silicosis.

关 键 词：着色芽生菌病 Fonsecaea monophora 伊曲康唑 

分 类 号：R519.2[医药卫生—内科学]