盐酸特比萘芬乳膏联合3%硼酸酒精滴耳液治疗真菌性外耳道炎的效果  

Effect of terbinafine hydrochloride cream combined with 3%boric acid alcohol ear drops on fungal otitis externa

作　　者：杜昱聪 刘环海 DU Yucong;LIU Huanhai(Department of Otorhinolaryngology Head and Neck Surgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China)

机构地区：[1]海军军医大学附属长征医院耳鼻咽喉科,上海200003

出　　处：《中国真菌学杂志》2022年第3期227-230,共4页Chinese Journal of Mycology

基　　金：国家自然科学基金(81870702)。

摘　　要：目的探究盐酸特比萘芬乳膏(terbinafine hydrochloride cream,THC)联合3%硼酸酒精(boric acid alcohol,BAA)滴耳液治疗真菌病的临床疗效。方法选取144例在我院治疗的真菌性外耳道炎患者作为研究对象,将患者随机分为A组和B组,A组采用3%BAA和THC联合治疗,B组单用BAA治疗。比较分析两组患者的治疗效果及真菌培养结果。结果A组的治疗有效率及临床疗效评分明显优于B组(P<0.05);A组在瘙痒、耳溢、耳鸣这3个症状的改善较B组更明显(P<0.05);真菌培养中曲霉占57.7%,念珠菌占22.5%,并且对特比萘芬的敏感性高。结论THS联合3%BAA滴耳液治疗真菌性外耳道炎的有效方法。Objective To explore the clinical efficacy of THC combined with 3%baa ear drops in the treatment of mycosis.Methods A total of 144 patients with external auditory canal mycosis treated in our hospital were enrolled.The patients were randomly divided into group A and group B.Group A was treated with 3%BAA and THC,and group B was treated with BAA alone.The therapeutic effects and fungal culture results of the two groups were compared and analyzed.Results The cure rate and clinical efficacy score of group A were significantly higher than those of group B(P<0.05);The improvement of pruritus,otorrhea and tinnitus in group A was more obvious than that in group B(P<0.05);Aspergillus and Candida accounted for 57.7%and 22.5%in the positive fungal culture,and they were highly sensitive to terbinafine.ConclusionTHC combined with 3%baa ear drops is an effective method for the treatment of fungal otitis externa.

关 键 词：特比萘芬 硼酸 真菌性外耳道炎 

分 类 号：R763[医药卫生—耳鼻咽喉科]