多取代2-吡喃酮-3-甲酸的合成与表征  

Synthesis and characterization of polysubstituted 2-pyranone-3-formic acid compounds

作　　者：任传清[1,2] 寇高翔 邵先钊[1] 季晓晖[1] 季建伟[1] 张强[1] REN Chuan-qing;KOU Gao-xiang;SHAO Xian-zhao;JI Xiao-hui;JI Jian-wei;ZHANG Qiang(Shaanxi Key Laboratory of Catalysis,Shaanxi University of Technology,Hanzhong 723000,China;School of Chemical and Environmental Science,Shaanxi Univrsity of Technology,Hanzhong 723000,China)

机构地区：[1]陕西理工大学,陕西省催化基础与应用重点实验室,陕西汉中723000 [2]陕西理工大学,化学与环境科学学院,陕西汉中723000

出　　处：《化学研究与应用》2022年第6期1411-1416,共6页Chemical Research and Application

基　　金：陕西省科技厅自然科学基础研究计划项目(2020JM-602)资助;陕西省教育厅基金项目(19JS011)资助;陕西省教育厅重点项目(20JS015)资助。

摘　　要：吡喃酮类衍生物是一类具有生物活性的六元杂环化合物,同时,许多吡喃酮类化合物还是重要的有机合成中间体,广泛应用到医药,农药的合成中。本论文以氢氧化钠为碱,2-二乙硫基亚甲基乙酰乙酰苯胺和丙二腈合成了一系列新型多取代2-吡喃酮-3-甲酸,通过核磁共振、质谱分析对所得化合物的结构进行表征,并对该反应合成机理进行了探讨。该合成方法条件温和、操作安全、收率高。Pyranones and their derivatives are one of the impertant six-membered heterocyclic compounds with biological activity,and are used as promising intermediates in the synthesis of pharmacy and pesticides.A series of novel polysubstituted 2-pyranone-3-formic acid compounds were synthesized from 2-bis(ethylthio)methylene acetoacetanilide and malononitrile in the presence of sodium hydroxide.The composition and structure had been characterized by ^(1)H NMR,^(13)C NMR and HR-MS.Moreover,the mechanism for the reaction was proposed in this paper.The reported synthesis had the advantages of mild conditions,safe operation and higher yields.

关 键 词：乙酰乙酰苯胺 2-吡喃酮-3-甲酸 氢氧化钠 

分 类 号：O626.2[理学—有机化学]