外泌体复合支架用于口腔组织工程的研究进展  

Research progress on exosome composite scaffolds in oral tissue engineering

作　　者：蔡超莹 陈学鹏[1] 胡济安[2] Cai Chaoying;Chen Xuepeng;Hu Ji’an(Dept.of Orthodontics,The Affiliated Hospital of Stomatology,Zhejiang University School of Medicine,School of Stomatology,Zhejiang University,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou 310006,China;Dept.of Pathology,The Affiliated Hospital of Stomatology,Zhejiang University School of Medicine,School of Stomatology,Zhejiang University,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属口腔医院正畸科,浙江大学口腔医学院,浙江省口腔生物医学研究重点实验室,杭州310006 [2]浙江大学医学院附属口腔医院病理科,浙江大学口腔医学院,浙江省口腔生物医学研究重点实验室,杭州310006

出　　处：《国际口腔医学杂志》2022年第4期489-496,共8页International Journal of Stomatology

基　　金：浙江省自然科学基金(LY18H140001)。

摘　　要：口腔颌面部组织缺损会严重影响患者的美观与功能,有效修复缺损是当前临床工作的重点。口腔组织工程通过支架、生长因子及干细胞等的应用,实现了组织再生与功能重建。干细胞与支架的复合材料以其良好的再生性能广泛应用于口腔组织再生,但干细胞生物相容性差、可用率低,存在临床应用瓶颈。外泌体相较于干细胞免疫原性低、产量高,有望代替干细胞应用于临床。日益丰富的支架材料与结构可有效保护并递送外泌体到达靶组织。目前,有关外泌体复合支架应用的研究覆盖了颌骨、关节软骨、牙髓及牙周组织再生。本文就外泌体复合支架在口腔颌面部组织再生中的研究作一综述。Defects in various oral and maxillofacial tissues will seriously affect the appearance and function of patients,and effective repair of the defects is the focus of current clinical work.Oral tissue engineering achieves tissue regeneration and functional reconstruction through the application of scaffolds,growth factors and stem cells.The composite materials of stem cells and scaffolds are widely used in the regeneration of oral tissues due to their good regeneration performance.However,the stem cells have poor biocompatibility and low availability,inducing a bottleneck in clinical application.Compared with stem cells,exosomes have lower immunogenicity and higher yield,and are expected to replace stem cells in clinical application.Increasingly abundant scaffold materials can effectively protect and deliver exosomes to target tissues.At present,researches on the application of exosome composite scaffolds have covered the regeneration of jaw bone,articular cartilage,pulp and periodontal tissues.This article reviews the researches upon exosome composite scaffolds in the regeneration of oral and maxillofacial tissues.

关 键 词：口腔组织工程 外泌体 支架 骨再生 软骨再生 牙髓再生 牙周再生 

分 类 号：Q254[生物学—细胞生物学]